Product Elements:
Chloramphenicol sodium succinate chloramphenicol sodium succinate chloramphenicol sodium succinate chloramphenicol
Drug Interactions:
Drug interactions concurrent therapy with other drugs that may cause bone marrow depression should be avoided.
Boxed Warning:
Warning serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia) are known to occur after the administration of chloramphenicol. in addition, there have been reports of aplastic anemia attributed to chloramphenicol which later terminated in leukemia. blood dyscrasias have occurred after both short-term and prolonged therapy with this drug. chloramphenicol must not be used when less potentially dangerous agents will be effective, as described in the indications and usage section. it must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat; or as a prophylactic agent to prevent bacterial infections. precautions: it is essential that adequate blood studies be made during treatment with the drug. while blood studies may detect early peripheral blood changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before they become irreversible, such studies cannot be relied on to detect bone marrow depression prior to development of aplastic anemia. to facilitate appropriate studies and observation during therapy, it is desirable that patients be hospitalized.
General Precautions:
General repeated courses of chloramphenicol treatment should be avoided if at all possible. treatment should not be continued longer than required to produce a cure with little or no risk or relapse of the disease. excessive blood levels may result from administration of the recommended dose to patients with impaired liver or kidney function. the dosage should be adjusted accordingly, or preferably, the blood concentration should be determined at appropriate intervals. the use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. if infections caused by nonsusceptible organisms appear during therapy, appropriate measures should be taken.
Contraindications:
Contraindications: chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it. it must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat; or as a prophylactic agent to prevent bacterial infections.
Adverse Reactions:
Adverse reactions: blood dyscrasias the most serious adverse effect of chloramphenicol is bone marrow depression. serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol. an irreversible type of marrow depression leading to aplastic anemia with a high rate of mortality is characterized by the appearance weeks or months after therapy of bone marrow aplasia or hypoplasia. peripherally, pancytopenia is most often observed, but in a small number of cases only one or two of the three major cell types (erythrocytes, leukocytes, platelets) may be depressed. a reversible type of bone marrow depression, which is dose related, may occur. this type of marrow depression is characterized by vacuolization of the erythroid cells, reduction of reticulocytes and leukopenia, and responds promptly to the withdrawal of chloramphenicol. an exact determination of the risk of serious and fa
Read more...tal blood dyscrasias is not possible because of lack of accurate information regarding 1) the size of the population at risk, 2) the total number of drug-associated dyscrasias, and 3) the total number of non-drug associated dyscrasias. in a report to the california state assembly by the california medical association and the state department of public health in january 1967, the risk of fatal aplastic anemia was estimated at 1:24,200 to 1:40,500 based on two dosage levels. there have been reports of aplastic anemia attributed to chloramphenicol which later terminated in leukemia. paroxysmal nocturnal hemoglobinuria has been reported. gastrointestinal reactions nausea, vomiting, glossitis and stomatitis, diarrhea and enterocolitis may occur in low incidence. neurotoxic reactions headache, mild depression, mental confusion, and delirium have been described in patients receiving chloramphenicol. optic and peripheral neuritis have been reported, usually following long-term therapy. if this occurs, the drug should be promptly withdrawn. hypersensitivity reactions fever, macular and vesicular rashes, angioedema, urticaria, and anaphylaxis may occur. herxheimerâs reactions have occurred during therapy for typhoid fever. "gray syndrome" toxic reactions including fatalities have occurred in the premature and neonate; the signs and symptoms associated with these reactions have been referred to as the âgray syndrome.â one case of gray syndrome has been reported in a neonate born to a mother having received chloramphenicol during labor. one case has been reported in a 3-month-old infant. the following summarizes the clinical and laboratory studies that have been made on these patients: a) in most cases therapy with chloramphenicol had been instituted within the first 48 hours of life. b) symptoms first appeared after 3 to 4 days of continued treatment with high doses of chloramphenicol. c) the symptoms appeared in the following order: (1) abdominal distension with or without emesis; (2) progressive pallid cyanosis; (3) vasomotor collapse, frequently accompanied by irregular respiration; (4) death within a few hours of onset of these symptoms. d) the progression of symptoms from onset to exitus was accelerated with higher dose schedules. e) preliminary blood serum level studies revealed unusually high concentrations of chloramphenicol (over 90 mcg/ml after repeated doses). f) termination of therapy upon early evidence of the associated symptomatology frequently reversed the process with complete recovery.
Blood dyscrasias the most serious adverse effect of chloramphenicol is bone marrow depression. serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol. an irreversible type of marrow depression leading to aplastic anemia with a high rate of mortality is characterized by the appearance weeks or months after therapy of bone marrow aplasia or hypoplasia. peripherally, pancytopenia is most often observed, but in a small number of cases only one or two of the three major cell types (erythrocytes, leukocytes, platelets) may be depressed. a reversible type of bone marrow depression, which is dose related, may occur. this type of marrow depression is characterized by vacuolization of the erythroid cells, reduction of reticulocytes and leukopenia, and responds promptly to the withdrawal of chloramphenicol. an exact determination of the risk of serious and fatal blood dyscrasia
Read more...s is not possible because of lack of accurate information regarding 1) the size of the population at risk, 2) the total number of drug-associated dyscrasias, and 3) the total number of non-drug associated dyscrasias. in a report to the california state assembly by the california medical association and the state department of public health in january 1967, the risk of fatal aplastic anemia was estimated at 1:24,200 to 1:40,500 based on two dosage levels. there have been reports of aplastic anemia attributed to chloramphenicol which later terminated in leukemia. paroxysmal nocturnal hemoglobinuria has been reported.
Gastrointestinal reactions nausea, vomiting, glossitis and stomatitis, diarrhea and enterocolitis may occur in low incidence.
Neurotoxic reactions headache, mild depression, mental confusion, and delirium have been described in patients receiving chloramphenicol. optic and peripheral neuritis have been reported, usually following long-term therapy. if this occurs, the drug should be promptly withdrawn.
Hypersensitivity reactions fever, macular and vesicular rashes, angioedema, urticaria, and anaphylaxis may occur. herxheimerâs reactions have occurred during therapy for typhoid fever.
"gray syndrome" toxic reactions including fatalities have occurred in the premature and neonate; the signs and symptoms associated with these reactions have been referred to as the âgray syndrome.â one case of gray syndrome has been reported in a neonate born to a mother having received chloramphenicol during labor. one case has been reported in a 3-month-old infant. the following summarizes the clinical and laboratory studies that have been made on these patients: a) in most cases therapy with chloramphenicol had been instituted within the first 48 hours of life. b) symptoms first appeared after 3 to 4 days of continued treatment with high doses of chloramphenicol. c) the symptoms appeared in the following order: (1) abdominal distension with or without emesis; (2) progressive pallid cyanosis; (3) vasomotor collapse, frequently accompanied by irregular respiration; (4) death within a few hours of onset of these symptoms. d) the progression of symptoms from onset to exitus wa
Read more...s accelerated with higher dose schedules. e) preliminary blood serum level studies revealed unusually high concentrations of chloramphenicol (over 90 mcg/ml after repeated doses). f) termination of therapy upon early evidence of the associated symptomatology frequently reversed the process with complete recovery.
Drug Interactions:
Drug interactions concurrent therapy with other drugs that may cause bone marrow depression should be avoided.
Use in Pregnancy:
Pregnancy pregnancy category c â animal reproduction studies have not been conducted with chloramphenicol. there are no adequate and well-controlled studies to establish safety of this drug in pregnancy. it is not known whether chloramphenicol can cause fetal harm when administered to a pregnant woman. orally administered chloramphenicol has been shown to cross the placental barrier. because of potential toxic effects on the fetus (see adverse reactions, âgray syndromeâ ), chloramphenicol should be given to a pregnant woman only if the potential benefit justifies the potential risk to the fetus.
Pediatric Use:
Pediatric use precaution should be used in therapy of premature and full-term neonates and infants to avoid âgray syndromeâ toxicity. due to immature metabolic processes in the neonate and infant, excessive blood levels may result from administration of the recommended dose. the dosage should be adjusted accordingly or, preferable, the blood concentration should be determined at appropriate intervals (see adverse reactions , "gray syndrome" ). see dosage and administration for dosing information in the pediatric population.
Geriatric Use:
Geriatric use clinical studies of chloramphenicol sodium succinate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. other reported clinical experience has not identified differences in responses between the elderly and younger patients. in general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. this drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. each gram (10 ml of a 10% solution) of chloramphenicol sodium succinate contains approximately 52 mg (2.25 meq) of sodium.
Description:
Description: chloramphenicol is an antibiotic that is clinically useful for, and should be reserved for, serious infections caused by organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. sensitivity testing is essential to determine its indicated use, but may be performed concurrently with therapy initiated on clinical impression that one of the indicated conditions exists (see indications and usage section). when reconstituted as directed, each vial contains a sterile solution equivalent to 100 mg of chloramphenicol per ml (1 g/10 ml). each gram (10 ml of a 10% solution) of chloramphenicol sodium succinate contains approximately 52 mg (2.25 meq) of sodium. the chemical name for chloramphenicol sodium succinate is d-threo-(-)-2, 2-dichloro-n-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium succinate). the structural formula is: structure
Clinical Pharmacology:
Clinical pharmacology: chloramphenicol administered orally is absorbed rapidly from the intestinal tract. in controlled studies in adult volunteers using the recommended dosage of 50 mg/kg/day, a dosage of 1 g every 6 hours for 8 doses was given. using the microbiological assay method, the average peak serum level was 11.2 mcg/ml one hour after the first dose. a cumulative effect gave a peak rise to 18.4 mcg/ml after the fifth dose of 1 g. mean serum levels ranged from 8 to 14 mcg/ml over the 48-hour period. total urinary excretion of chloramphenicol in these studies ranged from a low of 68% to a high of 99% over a three-day period. from 8% to 12% of the antibiotic excreted is in the form of free chloramphenicol; the remainder consists of microbiologically inactive metabolites, principally the conjugate with glucuronic acid. since the glucuronide is excreted rapidly, most chloramphenicol detected in the blood is in the microbiologically active free form. despite the small proportion of
Read more... unchanged drug excreted in the urine, the concentration of free chloramphenicol is relatively high, amounting to several hundred mcg/ml in patients receiving divided doses of 50 mg/kg/day. small amounts of active drug are found in bile and feces. chloramphenicol diffuses rapidly, but its distribution is not uniform. highest concentrations are found in liver and kidney, and lowest concentrations are found in brain and cerebrospinal fluid. chloramphenicol enters cerebrospinal fluid even in the absence of meningeal inflammation, appearing in concentrations about half of those found in the blood. measurable levels are also detected in pleural and in ascitic fluids, saliva, milk, and in the aqueous and vitreous humors. transport across the placental barrier occurs with somewhat lower concentration in cord blood of neonates than in maternal blood. microbiology mechanism of action chloramphenicol is a broad-spectrum antibiotic originally isolated from streptomyces venezuelae . it inhibits bacterial protein synthesis by interfering with the transfer of activated amino acids from soluble rna to ribosomes. in vitro, chloramphenicol exerts mainly a bacteriostatic effect on a wide range of gram-negative and gram-positive bacteria. antimicrobial activity chloramphenicol has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the indications and usage section. aerobic gram-negative microorganisms haemophilus influenzae salmonella species, including salmonella typhi other microorganisms lymphogranuloma-psittacosis group rickettsia susceptibility testing methods when available, the clinical microbiology laboratory should provide cumulative reports of in vitro susceptibility test results for antimicrobial drugs used in local hospitals and practice areas to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. these reports should aid the physician in selecting an antibacterial drug for treatment. dilution techniques quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (mics). these mics provide estimates of the susceptibility of bacteria to antimicrobial compounds. the mics should be determined using a standardized (broth and/or agar). 1,3 the mic values should be interpreted according to the criteria provided in table 1. diffusion techniques quantitative methods that require measurement of zone diameters can also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. the zone size should be determined using a standardized test method. 2,3 this procedure uses paper disks impregnated with 30 mcg chloramphenicol to test the susceptibility of bacteria to chloramphenicol. the disc diffusion breakpoints should be interpreted according to the criteria provided in table 1. table 1. susceptibility test interpretive criteria for chloramphenicol pathogen minimum inhibitory concentrations (mcg/ml) zone diameters (mm) s i r s i r salmonella spp. < 8 16 > 32 > 18 13 to 17 < 12 haemophilus influenzae < 2 4 > 8 ⥠29 26 to 28 < 25 a report of susceptible (s) indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the site of infection. a report of intermediate (i) indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. this category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of the drug can be used. this category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. a report of resistant (r) indicates that the antimicrobial drug is not likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the infection site; other therapy should be selected. quality control standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of supplies and reagents used in the assay, and the techniques of the individuals performing the test. 1,2,3 standard chloramphenicol powder should provide the following range of mic values noted in table 2. for the disc diffusion technique using the 30 mcg disk, the criteria in table 2 should be achieved. table 2. quality control parameters for chloramphenicol qc strain minimum inhibitory concentrations (mcg/ml) zone diameters (mm) escherichia coli atcc 25922 2 to 8 21 to 27 haemophilus influenzae atcc 49247 0.25 to 1 31 to 40
Susceptibility testing methods when available, the clinical microbiology laboratory should provide cumulative reports of in vitro susceptibility test results for antimicrobial drugs used in local hospitals and practice areas to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. these reports should aid the physician in selecting an antibacterial drug for treatment. dilution techniques quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (mics). these mics provide estimates of the susceptibility of bacteria to antimicrobial compounds. the mics should be determined using a standardized (broth and/or agar). 1,3 the mic values should be interpreted according to the criteria provided in table 1. diffusion techniques quantitative methods that require measurement of zone diameters can also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. the
Read more... zone size should be determined using a standardized test method. 2,3 this procedure uses paper disks impregnated with 30 mcg chloramphenicol to test the susceptibility of bacteria to chloramphenicol. the disc diffusion breakpoints should be interpreted according to the criteria provided in table 1. table 1. susceptibility test interpretive criteria for chloramphenicol pathogen minimum inhibitory concentrations (mcg/ml) zone diameters (mm) s i r s i r salmonella spp. < 8 16 > 32 > 18 13 to 17 < 12 haemophilus influenzae < 2 4 > 8 ⥠29 26 to 28 < 25 a report of susceptible (s) indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the site of infection. a report of intermediate (i) indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. this category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of the drug can be used. this category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. a report of resistant (r) indicates that the antimicrobial drug is not likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the infection site; other therapy should be selected. quality control standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of supplies and reagents used in the assay, and the techniques of the individuals performing the test. 1,2,3 standard chloramphenicol powder should provide the following range of mic values noted in table 2. for the disc diffusion technique using the 30 mcg disk, the criteria in table 2 should be achieved. table 2. quality control parameters for chloramphenicol qc strain minimum inhibitory concentrations (mcg/ml) zone diameters (mm) escherichia coli atcc 25922 2 to 8 21 to 27 haemophilus influenzae atcc 49247 0.25 to 1 31 to 40
Carcinogenesis and Mutagenesis and Impairment of Fertility:
Carcinogenesis, mutagenesis, impairment of fertility no studies have been conducted in animals or humans to evaluate the possibility of these effects with chloramphenicol.
How Supplied:
How supplied: chloramphenicol sodium succinate for injection, usp is freeze-dried in the vial. when reconstituted as directed, each vial contains a sterile solution equivalent to 100 mg of chloramphenicol per ml (1 g/10 ml). product no. ndc no. 1115 63323-011-15 available in packages of 10 vials. preservative free. store at 20° to 25°c (68° to 77°f) [see usp controlled room temperature].
Package Label Principal Display Panel:
Package label - principal display - chloramphenicol sodium succinate 1 gram vial label chloramphenicol sodium succinate for injection, usp 1 gram per vial for intravenous use only. preservative free. rx only package label - principal display - chloramphenicol sodium succinate 1 gram vial tray label chloramphenicol sodium succinate for injection, usp 1 gram per vial for intravenous use only. preservative free. 10 x 1 g vials rx only vial tray