um and hydrochlorothiazide and lithium should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. antacids in a clinical pharmacology study, serum levels and urinary excretion of fosinoprilat were reduced when fosinopril was coadministered with an antacid (aluminum hydroxide, magnesium hydroxide, and simethicone) suggesting that antacids may impair absorption of fosinopril. if concomitant administration of these agents is indicated, dosing should be separated by 2 hours. gold nitritoid reactions (symptoms include facial flushing, nausea, vomiting, and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ace inhibitor therapy including fosinopril sodium and hydrochlorothiazide. other the bioavailability of unbound fosinoprilat is not altered by coadministration of fosinopril with aspirin, chlorthalidone, cimetidine, digoxin, metoclopramide, nifedipine, propranolol, propantheline, or warfarin . other ace inhibitors have had less than additive effects with beta-adrenergic blockers , presumably because drugs of both classes lower blood pressure by inhibiting parts of the renin-angiotensin system. interaction studies with warfarin have failed to identify any clinically important effects of fosinopril on the serum concentration or clinical effects of the anticoagulant. insulin requirements in diabetic patients may be increased, decreased, or unchanged. thiazides may decrease arterial responsiveness to norepinephrine , but not enough to preclude effectiveness of the pressor agent for therapeutic use. thiazides may increase the responsiveness to tubocurarine. the diuretic, natriuretic, and antihypertensive effects of thiazide diuretics may be reduced by concurrent administration of nonsteroidal anti-inflammatory agents ; the effects (if any) of these agents on the antihypertensive effect of fosinopril sodium and hydrochlorothiazide have not been studied. by alkalinizing the urine, hydrochlorothiazide may decrease the effectiveness of methenamine. cholestyramine and colestipol resins absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85% and 43%, respectively. dual blockade of the renin-angiotensin system (ras) dual blockade of the ras with angiotensin receptor blockers, ace inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. closely monitor blood pressure, renal function and electrolytes in patients on fosinopril and hydrochlorothiazide and other agents that affect the ras. do not co-administer aliskiren with fosinopril and hydrochlorothiazide in patients with diabetes. avoid use of aliskiren with fosinopril and hydrochlorothiazide in patients with renal impairment (gfr <60 ml/min).

y administered (see precautions and adverse reactions ). intestinal angioedema intestinal angioedema has been reported in patients treated with ace inhibitors. these patients presented with abdominal pain (with or without nausea or vomiting); in some cases there was no prior history of facial angioedema and c-1 esterase levels were normal. the angioedema was diagnosed by procedures including abdominal ct scan or ultrasound, or at surgery, and symptoms resolved after stopping the ace inhibitor. intestinal angioedema should be included in the differential diagnosis of patients on ace inhibitors presenting with abdominal pain. anaphylactoid reactions during desensitization two patients undergoing desensitizing treatment with hymenoptera venom while receiving ace inhibitors sustained life-threatening anaphylactoid reactions. in the same patients, these reactions were avoided when ace inhibitors were temporarily withheld, but they reappeared upon inadvertent rechallenge. anaphylactoid reactions during membrane exposure anaphylactoid reactions have been reported in patients dialyzed with high-flux membranes and treated concomitantly with an ace inhibitor. anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption. hypotension fosinopril sodium and hydrochlorothiazide can cause symptomatic hypotension. like other ace inhibitors, fosinopril has been only rarely associated with hypotension in uncomplicated hypertensive patients. symptomatic hypotension is most likely to occur in patients who have been volume- and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. volume and/or salt depletion should be corrected before initiating therapy with fosinopril sodium and hydrochlorothiazide. fosinopril sodium and hydrochlorothiazide tablets should be used cautiously in patients receiving concomitant therapy with other antihypertensives. the thiazide component of fosinopril sodium and hydrochlorothiazide may potentiate the action of other antihypertensive drugs, especially ganglionic or peripheral adrenergic-blocking drugs. the antihypertensive effects of the thiazide component may also be enhanced in the post-sympathectomy patient. in patients with congestive heart failure, with or without associated renal insufficiency, ace inhibitor therapy may cause excessive hypotension, which may be associated with oliguria, azotemia, and (rarely) with acute renal failure and death. in such patients, fosinopril sodium and hydrochlorothiazide therapy should be started under close medical supervision; they should be followed closely for the first 2 weeks of treatment and whenever the dose of fosinopril or diuretic is increased. if hypotension occurs, the patient should be placed in a supine position, and, if necessary, treated with intravenous infusion of physiological saline. fosinopril sodium and hydrochlorothiazide treatment usually can be continued following restoration of blood pressure and volume. impaired renal function fosinopril sodium and hydrochlorothiazide should be used with caution in patients with severe renal disease. thiazides may precipitate azotemia in such patients, and the effects of repeated dosing may be cumulative. when the renin-angiotensin-aldosterone system is inhibited by ace inhibitors, changes in renal function may be anticipated in susceptible individuals. in patients with severe congestive heart failure, whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with angiotensin-converting enzyme inhibitors (including fosinopril) may be associated with oliguria and/or progressive azotemia and (rarely) with acute renal failure and/or death. in some studies of hypertensive patients with unilateral or bilateral renal artery stenosis, treatment with ace inhibitors has been associated with increases in blood urea nitrogen and serum creatinine; these increases were reversible upon discontinuation of ace inhibitor therapy, concomitant diuretic therapy, or both. when such patients are treated with fosinopril sodium and hydrochlorothiazide, renal function should be monitored during the first few weeks of therapy. some ace-inhibitor-treated hypertensive patients with no apparent preexisting renal vascular disease have developed increases in blood urea nitrogen and serum creatinine, usually minor and transient, especially when the ace inhibitor has been given concomitantly with a diuretic. dosage reduction of fosinopril sodium and hydrochlorothiazide may be required. evaluation of the hypertensive patient should always include assessment of renal function (see dosage and administration ). neutropenia/agranulocytosis another angiotensin-converting enzyme inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow depression, rarely in uncomplicated patients (incidence probably less than once per 10,000 exposures), but more frequently (incidence possibly as great as once per 1,000 exposures) in patients with renal impairment, especially those who also have a collagen-vascular disease such as systemic lupus erythematosus or scleroderma. available data from clinical trials of fosinopril are insufficient to show that fosinopril does not cause agranulocytosis at similar rates. monitoring of white blood cell counts should be considered in patients with collagen-vascular disease, especially if the disease is associated with impaired renal function. neutropenia/agranulocytosis has also been associated with thiazide diuretics. fetal toxicity pregnancy category d use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. when pregnancy is detected, discontinue fosinopril and hydrochlorothiazide as soon as possible. these adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. in the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus. perform serial ultrasound examinations to assess the intra-amniotic environment. if oligohydramnios is observed, discontinue fosinopril and hydrochlorothiazide, unless it is considered lifesaving for the mother. fetal testing may be appropriate, based on the week of pregnancy. patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. closely observe infants with histories of in utero exposure to fosinopril and hydrochlorothiazide for hypotension, oliguria, and hyperkalemia ( see precautions , pediatric use ). intrauterine exposure to thiazide diuretics is associated with fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that occurred in adults. no teratogenic effects of fosinopril were seen in studies of pregnant rats and rabbits. on a mg/kg basis, the doses used were up to 180 times (in rats) and one time (in rabbits) the maximum recommended human dose. no teratogenic effects of fosinopril and hydrochlorothiazide were seen in studies of pregnant rats and rabbits. on a mg/kg (fosinopril and hydrochlorothiazide) basis, the doses used were up to 188/94 times (in rats) and 0.6/0.3 times (in rabbits) the maximum recommended human dose. impaired hepatic function rarely, ace inhibitors have been associated with a syndrome that begins with cholestatic jaundice and progresses to fulminant hepatic necrosis and (sometimes) death. the mechanism of this syndrome is not understood. a patient receiving fosinopril sodium and hydrochlorothiazide who develops jaundice or marked elevation of hepatic enzymes should discontinue fosinopril sodium and hydrochlorothiazide tablets and receive appropriate medical follow-up. fosinopril sodium and hydrochlorothiazide should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. also, since the metabolism of fosinopril to fosinoprilat is normally dependent upon hepatic esterases, patients with impaired liver function could develop elevated plasma levels of fosinopril. in a study of patients with alcoholic or biliary cirrhosis the rate (but not the extent) of hydrolysis to fosinoprilat was reduced. in these patients the clearance of fosinoprilat was reduced, and the area under the fosinoprilat-time curve was approximately doubled. systemic lupus erythematosus thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus.

toxic effects of digitalis. the risk of hypokalemia is greatest in patients with cirrhosis of the liver, in patients experiencing a brisk diuresis, in patients who are receiving inadequate oral intake of electrolytes, and in patients receiving concomitant therapy with corticosteroids or acth. the opposite effects of fosinopril and hydrochlorothiazide on serum potassium will approximately balance each other in many patients, so that no net effect upon serum potassium will be seen. in other patients, one or the other effect may be dominant. initial and periodic determinations of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals. chloride deficits are generally mild and require specific treatment only under extraordinary circumstances (e.g., in liver disease or renal disease). dilutional hyponatremia may occur in edematous patients; appropriate therapy is water restriction rather than administration of salt, except in rare instances when the hyponatremia is life-threatening. in actual salt depletion, appropriate replacement is the therapy of choice. calcium excretion is decreased by thiazides. in a few patients on prolonged thiazide therapy, pathological changes in the parathyroid gland have been observed, with hypercalcemia and hypophosphatemia. more serious complications of hyperparathyroidism (renal lithiasis, bone resorption, and peptic ulceration) have not been seen. thiazides increase the urinary excretion of magnesium, and hypomagnesemia may result. other metabolic disturbances thiazide diuretics tend to reduce glucose tolerance and to raise serum levels of cholesterol, triglycerides, and uric acid. these effects are usually minor, but frank gout or overt diabetes may be precipitated in susceptible patients. cough presumably due to the inhibition of the degradation of endogenous bradykinin, persistent nonproductive cough has been reported with all ace inhibitors, always resolving after discontinuation of therapy. ace inhibitor-induced cough should be considered in the differential diagnosis of cough. surgery/anesthesia in patients undergoing surgery or during anesthesia with agents that produce hypotension, fosinopril will block the angiotensin ii formation that could otherwise occur secondary to compensatory renin release. hypotension that occurs as a result of this mechanism can be corrected by volume expansion.

ect with monotherapy. dose titration by clinical effect a patient whose blood pressure is not adequately controlled with fosinopril or hydrochlorothiazide monotherapy may be switched to combination therapy with fosinopril sodium and hydrochlorothiazide tablets. dosage must be guided by clinical response; controlled clinical trials showed that the addition of 12.5 mg of hydrochlorothiazide to 10 to 20 mg of fosinopril will typically be associated with additional reduction in seated diastolic blood pressure at 24 hours after dosing. on average, the effect of the combination of 10 mg of fosinopril with 12.5 mg of hydrochlorothiazide was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of hydrochlorothiazide. use in renal impairment in patients with severe renal impairment (creatinine clearance is <30 ml/min/1.73 m 2 , serum creatine roughly ?3 mg/dl or 265 µmol/l), loop diuretics are preferred to thiazides, so fosinopril sodium and hydrochlorothiazide tablets are not recommended. in patients with lesser degrees of renal impairment, fosinopril sodium and hydrochlorothiazide tablets may be used with no change in dosage.

o study drug that occurred in placebo-controlled trials in more than 2% of patients treated with fosinopril sodium and hydrochlorothiazide are shown in the table below. reactions possibly or probably drug-related (incidence in placebo-controlled studies) fosinopril sodium and hydrochlorothiazide (n=660) placebo (n=368) % % headache 7 12.8 cough 5.6 1.1 fatigue 3.9 2.4 dizziness 3.2 2.2 upper respiratory infection 2.3 2.7 musculoskeletal pain 2 1.9 other side effects considered possibly or probably related to study drug that occurred in controlled trials in 0.5% to <2% of patients treated with fosinopril sodium and hydrochlorothiazide, and rarer but clinically significant events regardless of causal relationship were: general: chest pain, weakness, fever, viral infection. cardiovascular: orthostatic hypotension (seen in 1.8% of fosinopril sodium and hydrochlorothiazide patients and 0.3% of placebo patients; no patients discontinued therapy due to orthostatic hypotension), edema, flushing, rhythm disturbance, syncope. dermatologic: pruritus, rash. endocrine/metabolic: sexual dysfunction, change in libido, breast mass. gastrointestinal: nausea/vomiting, diarrhea, dyspepsia/heartburn, abdominal pain, gastritis/esophagitis. immunologic: angioedema (see warnings: head and neck angioedema and intestinal angioedema ). musculoskeletal: myalgia/muscle cramps. neurologic/psychiatric: somnolence, depression, numbness/paresthesia. respiratory: sinus congestion, pharyngitis, rhinitis. special senses: tinnitus. urogenital: urinary tract infection, urinary frequency, dysuria. laboratory test abnormalities: serum electrolytes, uric acid, glucose, magnesium, cholesterol, triglycerides, and calcium (see precautions ). neutropenia. antihypertensive monotherapy with fosinopril has been evaluated for safety in more than 1500 patients, of whom approximately 450 patients were treated for a year or more. the observed adverse events included events similar to those seen with fosinopril sodium and hydrochlorothiazide; in addition, the following others have also been reported with fosinopril: cardiovascular: angina, myocardial infarction, cerebrovascular accident, hypertensive crisis, hypotension, claudication. dermatologic: urticaria, photosensitivity. endocrine/metabolic: gout. gastrointestinal: pancreatitis, hepatitis, dysphagia, abdominal distention, flatulence, appetite/weight change, dry mouth. hematologic: lymphadenopathy. musculoskeletal: arthralgia. neurologic/psychiatric: memory disturbance, tremor, confusion, mood change, sleep disturbance. respiratory: bronchospasm, laryngitis/hoarseness, epistaxis, and (in two patients) a symptom-complex of cough, bronchospasm, and eosinophilia. special senses: vision disturbance, taste disturbance, eye irritation. urogenital: renal insufficiency. laboratory test abnormalities: elevations (usually transient and minor) of bun and creatinine have been observed, but these have not been more frequent than in parallel patients treated with placebo. the hemoglobin in fosinopril-treated patients generally decreases by an average of 0.1 g/dl, but this nonprogressive change has never been symptomatic. leukopenia and eosinophilia have also been reported. serum levels of liver function tests (transaminases, ldh, alkaline phosphatase and serum bilirubin) have occasionally been found to be elevated, and these elevations have lead to discontinuation of therapy in 0.7% of patients. other risk factors for liver dysfunction have often been present in these cases; in any event the elevations generally have resolved after discontinuation of therapy with fosinopril. other adverse events reported with ace inhibitors other adverse effects reported with ace inhibitors include cardiac arrest; pancytopenia, hemolytic anemia; aplastic anemia; thrombocytopenia; bullous pemphigus, exfoliative dermatitis; and a syndrome that may include one or more of arthralgia/arthritis, vasculitis, serositis, myalgia, fever, rash or other dermopathy, positive ana titer, leukocytosis, eosinophilia, and elevated esr. hydrochlorothiazide has now been extensively prescribed for many years, but there has not been enough systematic collection of data to support an estimate of the frequency of the observed adverse reactions. within organ-system groups, the reported reactions are listed here in decreasing order of severity, without regard to frequency. cardiovascular: orthostatic hypotension (may be potentiated by alcohol, barbiturates, or narcotics). gastrointestinal: pancreatitis, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation, and anorexia. hematologic: aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, and hemolytic anemia. immunologic: necrotizing angiitis, stevens-johnson syndrome, respiratory distress (including pneumonitis and pulmonary edema), anaphylactic reactions, purpura, urticaria, rash, and photosensitivity. metabolic: hyperglycemia, glycosuria, and hyperuricemia. musculoskeletal: muscle spasm. neurologic: vertigo, lightheadedness, transient blurred vision, headache, paresthesia, xanthopsia, weakness, and restlessness. non-melanoma skin cancer hydrochlorothiazide is associated with an increased risk of non-melanoma skin cancer. in a study conducted in the sentinel system, increased risk was predominantly for squamous cell carcinoma (scc) and in white patients taking large cumulative doses. the increased risk for scc in the overall population was approximately 1 additional case per 16,000 patients per year, and for white patients taking a cumulative dose of ?50,000mg the risk increase was approximately 1 additional scc case for every 6,700 patients per year.

um and hydrochlorothiazide and lithium should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. antacids in a clinical pharmacology study, serum levels and urinary excretion of fosinoprilat were reduced when fosinopril was coadministered with an antacid (aluminum hydroxide, magnesium hydroxide, and simethicone) suggesting that antacids may impair absorption of fosinopril. if concomitant administration of these agents is indicated, dosing should be separated by 2 hours. gold nitritoid reactions (symptoms include facial flushing, nausea, vomiting, and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ace inhibitor therapy including fosinopril sodium and hydrochlorothiazide. other the bioavailability of unbound fosinoprilat is not altered by coadministration of fosinopril with aspirin, chlorthalidone, cimetidine, digoxin, metoclopramide, nifedipine, propranolol, propantheline, or warfarin . other ace inhibitors have had less than additive effects with beta-adrenergic blockers , presumably because drugs of both classes lower blood pressure by inhibiting parts of the renin-angiotensin system. interaction studies with warfarin have failed to identify any clinically important effects of fosinopril on the serum concentration or clinical effects of the anticoagulant. insulin requirements in diabetic patients may be increased, decreased, or unchanged. thiazides may decrease arterial responsiveness to norepinephrine , but not enough to preclude effectiveness of the pressor agent for therapeutic use. thiazides may increase the responsiveness to tubocurarine. the diuretic, natriuretic, and antihypertensive effects of thiazide diuretics may be reduced by concurrent administration of nonsteroidal anti-inflammatory agents ; the effects (if any) of these agents on the antihypertensive effect of fosinopril sodium and hydrochlorothiazide have not been studied. by alkalinizing the urine, hydrochlorothiazide may decrease the effectiveness of methenamine. cholestyramine and colestipol resins absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85% and 43%, respectively. dual blockade of the renin-angiotensin system (ras) dual blockade of the ras with angiotensin receptor blockers, ace inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. closely monitor blood pressure, renal function and electrolytes in patients on fosinopril and hydrochlorothiazide and other agents that affect the ras. do not co-administer aliskiren with fosinopril and hydrochlorothiazide in patients with diabetes. avoid use of aliskiren with fosinopril and hydrochlorothiazide in patients with renal impairment (gfr <60 ml/min).

tions . ) removal of angiotensin ii negative feedback on renin secretion leads to increased plasma renin activity. ace is identical to kininase, an enzyme that degrades bradykinin. whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of fosinopril sodium and hydrochlorothiazide tablets remains to be elucidated. while the mechanism through which fosinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, fosinopril has an antihypertensive effect even in patients with low-renin hypertension. hydrochlorothiazide is a thiazide diuretic. thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. the renin-aldosterone link is mediated by angiotensin, so coadministration of an ace inhibitor tends to reverse the potassium loss associated with these diuretics. the mechanism of the antihypertensive effect of thiazides is unknown. pharmacokinetics and metabolism the absolute absorption of fosinopril averages 36% of an oral dose. the primary site of absorption is the proximal small intestine. while the rate of absorption may be slowed by the presence of food in the gastrointestinal tract, the extent of absorption of fosinopril is essentially unaffected. following oral administration of hydrochlorothiazide, peak plasma concentrations are achieved in 1 to 2.5 hours, and the extent of absorption is 50 to 80%. the reported studies of food effects on hydrochlorothiazide absorption have been inconclusive. the absorption of hydrochlorothiazide is increased by agents that reduce gastrointestinal motility. it is reported to be decreased by 50% in patients with congestive heart failure. cleavage of the ester group (primarily in the liver) converts fosinopril to its active metabolite, fosinoprilat. the time to peak plasma concentrations of fosinoprilat is about 3 hours, independent of the administered dose of fosinopril. in patients with hepatic dysfunction due to cirrhosis, conversion of fosinopril to fosinoprilat may be slowed, but the extent of this conversion is unchanged. fosinoprilat is highly protein bound (95%), but has negligible binding to cellular components of blood. the peak serum concentration and the area under the concentration-time curve of fosinoprilat is directly proportional to the administered dose of fosinopril. after an oral dose of radiolabeled fosinopril, 75% of radioactivity in plasma was present as active fosinoprilat, 20 to 30% as a glucuronide conjugate of fosinoprilat, and 1 to 5% as a p -hydroxy metabolite of fosinoprilat. since fosinoprilat is not biotransformed after intravenous administration, fosinopril, not fosinoprilat, appears to be the precursor for the glucuronide and p -hydroxy metabolites. in rats, the p -hydroxy metabolite of fosinoprilat is as potent an inhibitor of ace as fosinoprilat; the glucuronide conjugate is devoid of ace inhibitory activity. studies in animals indicate that fosinopril and fosinoprilat do not cross the blood-brain barrier, but fosinoprilat does cross the placenta of pregnant animals. in humans, hydrochlorothiazide crosses the placenta freely, and levels in umbilical-cord blood are similar to those in the maternal circulation. hydrochlorothiazide is not metabolized. its apparent volume of distribution is 3.6 to 7.8 l/kg, and its measured plasma protein binding is 67.9%. the drug also accumulates in red blood cells, so that whole blood levels are 1.6 to 1.8 times those measured in plasma. after intravenous administration, fosinoprilat is eliminated approximately equally by the liver and kidney. after oral administration of radiolabeled fosinopril, approximately half of the absorbed dose is excreted in the urine and the remainder is excreted in the feces. in two studies involving healthy subjects, the mean body clearance of intravenous fosinoprilat was between 26 and 39 ml/min. in hypertensive patients with normal renal and hepatic function, the effective half-life of accumulation of fosinoprilat following multiple dosing of fosinopril sodium is 11.5 hours. thus, steady-state concentrations of fosinoprilat should be reached after 2 or 3 doses of fosinopril sodium and hydrochlorothiazide given once daily. in patients with renal insufficiency (creatinine clearance <80 ml/min/1.73 m 2 ), the total body clearance of fosinoprilat is approximately one half of that in patients with normal renal function, while absorption, bioavailability, and protein binding are not appreciably altered. the clearance of fosinoprilat does not differ appreciably with the degree of renal insufficiency, because the diminished renal elimination is offset by increased hepatobiliary elimination. a modest increase in plasma auc levels (less than two times that in normals) was observed in patients with various degrees of renal insufficiency, including end-stage renal failure (creatinine clearance <10 ml/min/1.73 m 2 ). (see dosage and administration . ) fosinopril is not well dialyzed. clearance of fosinoprilat by hemodialysis and peritoneal dialysis averages 2% and 7%, respectively, of urea clearances. in patients with hepatic insufficiency (alcoholic or biliary cirrhosis), the apparent total body clearance of fosinoprilat is approximately one half of that in patients with normal hepatic function. in elderly (male) subjects (65 to 74 years old) with clinically normal renal and hepatic function, there appear to be no significant differences in pharmacokinetic parameters for fosinoprilat compared to those of younger subjects (20 to 35 years old). thiazide diuretics are eliminated by the kidney, with a terminal half-life of 5 to 15 hours. in a study of patients with impaired renal function (mean creatinine clearance of 19 ml/min), the half-life of hydrochlorothiazide elimination was lengthened to 21 hours. when fosinopril and hydrochlorothiazide are administered concomitantly, the pharmacokinetics of hydrochlorothiazide are essentially unaffected. serum levels of fosinoprilat are increased after several weeks of coadministration of hydrochlorothiazide and fosinopril, but the increase is not sufficient to warrant any change in dosing. pharmacodynamics after single doses of 10 to 40 mg of fosinopril, serum ace activity was inhibited by at least 90% from 2 to 12 hours after dosing. at 24 hours, serum ace activity remains suppressed by 85 to 93%. administration of fosinopril to patients with mild to moderate hypertension results in a reduction of both supine and standing blood pressure to about the same extent with no compensatory tachycardia. in studies in hypertensive patients after three months of fosinopril monotherapy, hemodynamic responses to various stimuli (isometric exercise, 45° head-up tilt, mental challenges) were unchanged compared to baseline, suggesting that fosinopril did not affect the activity of the sympathetic nervous system. instead, fosinopril-induced reduction in blood pressure appears to be mediated by a reduction in peripheral vascular resistance without reflex cardiac effects. in similar studies, renal, splanchnic, cerebral, and skeletal-muscle blood flows were all unchanged compared to baseline, as was glomerular filtration rate. symptomatic postural hypotension is infrequent, although it can occur in patients who are salt- and/or volume-depleted (see warnings ). following oral administration of single doses of 10 to 40 mg, fosinopril lowered blood pressure within one hour, with peak reductions achieved 2 to 6 hours after dosing. the antihypertensive effect of a single dose persisted for 24 hours. following four weeks of monotherapy in placebo-controlled trials in patients with mild to moderate hypertension, once-daily doses of 20 to 80 mg lowered supine or seated blood pressures (systolic/diastolic) 24 hours after dosing by an average of 8 to 9/6 to 7 mmhg more than placebo. the trough effect was about 50 to 60% of the peak diastolic response and about 80% of the peak systolic response. in clinical studies of various combinations that included 0 to 40 mg of fosinopril and 0 to 37.5 mg of hydrochlorothiazide, the antihypertensive effects were increased with increasing dose of either component. peak blood pressure reductions were achieved 2 to 6 hours after dosing. the mean reductions in seated blood pressure (systolic/diastolic) associated with fosinopril sodium and hydrochlorothiazide tablets 10/12.5 after 24 hours were 9 to 18/5 to 7 mmhg greater than those associated with placebo; those associated with fosinopril sodium and hydrochlorothiazide 20/12.5 after 24 hours were 12 to 17/8 to 10 mmhg greater than those associated with placebo. these trough effects were 60 to 90% of the corresponding peak effects. although hydrochlorothiazide tends to be more effective in low-renin hypertensive patients (mainly blacks), and fosinopril—like other ace inhibitors—tends to be more effective in high-renin patients (mainly non-blacks), the effectiveness of fosinopril sodium and hydrochlorothiazide is independent of race, age, and gender.

rd mutation assay, or a mitotic gene conversion assay. fosinopril was also not genotoxic in a mouse micronucleus test in vivo and a mouse bone marrow cytogenetic assay in vivo . in chinese hamster ovary cell cytogenetic assay, fosinopril increased the frequency of chromosomal aberrations when tested without metabolic activation at a concentration that was toxic to the cells. however, there was no increase in chromosomal aberrations at lower drug concentrations without metabolic activation or at any concentration with metabolic activation. there were no adverse reproductive effects in male and female rats treated with up to 60 mg/kg daily. at doses 4 times higher, slight increases in pairing time were seen. this higher dose is about 125 (body surface area basis) or 600 (body-weight basis) times greater than the dose received by a 50 kg human receiving 20 mg a day. hydrochlorothiazide under the auspices of the national toxicology program, rats and mice received hydrochlorothiazide for two years at doses up to 100 (rats) and 600 (mice) mg/kg/day. on a body weight basis, these highest doses were about 2400 times (mice) or 400 times (rats) the fosinopril sodium and hydrochlorothiazide dose of 12.5 mg, given to a 50 kg subject. on a body surface area basis, these doses are 226 times (mice) and 82 times (rats) the fosinopril sodium and hydrochlorothiazide dose. these studies uncovered no evidence of carcinogenicity in rats or female mice, but there was equivocal evidence of hepatocarcinogenicity in male mice. hydrochlorothiazide was not genotoxic in in vitro assays using strains ta 98, ta 100, ta 1535, ta 1537, and ta 1538 of salmonella typhimurium (ames assay); in the chinese hamster ovary (cho) test for chromosomal aberrations; or in in vivo assays using mouse germinal cell chromosomes; chinese hamster bone-marrow chromosomes, and the drosophila sex-linked recessive lethal trait gene. using concentrations of hydrochlorothiazide of 43 to 1300 mg/ml, positive test results were obtained in the in vitro cho sister chromatid exchange (clastogenicity) test and in the mouse lymphoma cell (mutagenicity) assays. using an unspecified concentration of hydrochlorothiazide, positive test results were also obtained in the aspergillus nidulans nondisjunction assay. no adverse effects upon fertility were seen when rats and mice received dietary hydrochlorothiazide prior to mating and throughout gestation at doses up to 4 (rats) and 100 (mice) mg/kg/day. these doses are from 3.2 (body surface area basis in rats) to 400 (weight basis in mice) times greater than the dose received by a 50 kg human receiving 12.5 mg a day.

ysician. the patients should be told that if syncope occurs, fosinopril sodium and hydrochlorothiazide should be discontinued until the physician has been consulted. all patients should be cautioned that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope. hyperkalemia a patient receiving fosinopril sodium and hydrochlorothiazide should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician. neutropenia patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia.