low in the cerebral area for viewing intra-operative blood flow in the cerebral area with olympus infrared compatible video microscopic imaging system

esent, discard the solution. 5.3 drug/laboratory test interactions radioactive iodine uptake studies should not be performed for at least a week following the use of indocyanine green for injection usp.

usp is 3.0 mg (1.2 ml). immediately follow each icg intravenous injection with a tight bolus injection of approximately 10 - 12 ml of normal saline at least 30 minutes prior to ir imaging. multiple administrations can be performed, up to 2 mg/kg (0.8 ml/kg) per patient. for viewing intra-operative blood flow in the cerebral area ( 2.3 ) under sterile conditions, the indocyanine green for injection usp powder should be dissolved with the 10 ml sterile water for injection, usp provided and the solution used within 6 hours after it is prepared. the usual doses of indocyanine green for injection usp is 0.1 mg/kg (0.04 ml/kg) – 0.3 mg/kg (0.12 ml/kg). immediately follow each icg intravenous injection with a tight bolus injection of approximately 10 - 12 ml of normal saline immediately before ir imaging multiple administrations can be performed, up to 2 mg/kg (0.8 ml/kg) per patient. 2.1 visual assessment of blood vessels, blood flow and related tissue perfusion under sterile conditions, the indocyanine green for injection usp powder should be dissolved with the 10 ml sterile water for injection, usp provided for this product, and the solution used within 6 hours after it is prepared. if a precipitate is present, discard the solution. the patient should be weighed and the dosage for one administration should be calculated on the basis of 0.1 mg/kg (0.04 ml/kg) - 0.3 mg/kg (0.12 ml/kg) of body weight. multiple administrations can be performed, up to 2 mg/kg (0.8 ml/kg) per patient. icg should be administrated immediately before ir imaging. item note indocyanine green for injection, usp 25 mg vials of icg powder sterile water for injection (for dissolving icg) 10 ml vial of sterile water syringe (for injecting sterile water into the icg vial) use the syringe whose minimum volume is 10 ml syringes (for each administration) considering the administration volume, select the appropriate size sterile normal saline (for each saline flush) approximately 10 – 12 ml following each icg administration syringes (for each saline flush) use the syringe whose minimum volume is 12 ml prepare the syringes filled with the weight-scaled dose of icg solution, and the syringes filled with 10 - 12 ml of normal saline for the tight bolus injection. immediately before ir imaging, administer the prepared dose of icg solution intravenously. immediately follow each icg injection with a tight bolus injection of approximately 10 - 12 ml of normal saline. 2.2 visual assessment of the major extrahepatic bile duct under sterile conditions, the indocyanine green for injection usp powder should be dissolved with the 10 ml sterile water for injection, usp provided for this product, and the solution used within 6 hours after it is prepared. if a precipitate is present, discard the solution. the dosage for one administration should be 3.0 mg (1.2 ml) per patient. multiple administration can be performed, up to 2 mg/kg (0.8 ml/kg) per patient. icg should be administrated at least 30 minutes prior to ir imaging. item note indocyanine green for injection, usp 25 mg vials of icg powder sterile water for injection (for dissolving icg) 10 ml vial of sterile water syringe (for injecting sterile water into the icg vial) use the syringe whose minimum volume is 10 ml syringes (for each administration) considering the administration volume, select the appropriate size sterile normal saline (for each saline flush) approximately 10 – 12 ml following each icg administration syringes (for each saline flush) use the syringe whose minimum volume is 12 ml prepare the syringes filled with 3.0 mg (1.2 ml) of icg solution, and the syringes filled with 10 - 12 ml of normal saline for the tight bolus. at least 30 minutes prior to ir imaging, administer the prepared dose of icg solution intravenously. immediately follow each icg injection with a tight bolus injection of approximately 10 - 12 ml of normal saline. 2.3 viewing intra-operative blood flow in the cerebral area under sterile conditions, the indocyanine green for injection usp powder should be dissolved with the 10 ml sterile water for injection, usp provided for this product, and the solution used within 6 hours after it is prepared. if a precipitate is present, discard the solution. the patient should be weighed and the dosage for one administration should be calculated on the basis of 0.1 mg/kg (0.04 ml/kg) - 0.3 mg/kg (0.12 ml/kg) of body weight. multiple administration can be performed, up to 2 mg/kg (0.8 ml/kg) per patient. icg should be administrated immediately before ir imaging. item note indocyanine green for injection, usp 25 mg vials of icg powder sterile water for injection (for dissolving icg) 10 ml vial of sterile water syringe (for injecting sterile water into the icg vial) use the syringe whose minimum volume is 10 ml syringes (for each administration) considering the administration volume, select the appropriate size sterile normal saline (for each saline flush) approximately 10 – 12 ml following each icg administration syringes (for each saline flush) use the syringe whose minimum volume is 12 ml prepare the syringes filled with the weight-scaled dose of icg solution, and the syringes filled with 10 - 12 ml of normal saline for the tight bolus. immediately before ir imaging, administer the prepared dose of icg solution intravenously. immediately follow each icg injection with a tight bolus injection of approximately 10 - 12 ml of normal saline.

ll differences in safety or effectiveness have been observed between elderly and adult patients.

ake indocyanine green for injection usp a helpful index of hepatic function. the peak absorption and emission of indocyanine green for injection usp lie in a region (800 to 850 nm) where transmission of energy by the pigment epithelium is more efficient than in the region of visible light energy. indocyanine green for injection usp also has the property of being nearly 98% bound to blood protein, and therefore, excessive dye extravasation does not take place in the highly fenestrated choroidal vasculature. it is, therefore, useful in both absorption and fluorescence infrared angiography of the choroidal vasculature when using appropriate filters and film in a fundus camera. the plasma fractional disappearance rate at the recommended 0.5 mg/kg dose has been reported to be significantly greater in women than in men, although there was no significant difference in the calculated value for clearance.