Product Elements:
Vitamin d ergocalciferol ergocalciferol ergocalciferol fd&c yellow no. 5 gelatin, unspecified glycerin lecithin, soybean medium-chain triglycerides water ethylene glycol monoethyl ether soybean oil titanium dioxide shellac 194
Drug Interactions:
Drug interactions mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin d preparations. administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol capsules, usp may cause hypercalcemia.
Indications and Usage:
Indications and usage ergocalciferol capsules, usp are indicated for use in the treatment of hypoparathyroidism, refractory rickets, also known as vitamin d resistant rickets, and familial hypophosphatemia.
Warnings:
Warnings hypersensitivity to vitamin d may be one etiologic factor in infants with idiopathic hypercalcemia. in these cases vitamin d must be strictly restricted. keep out of the reach of children.
Dosage and Administration:
Dosage and administration the range between therapeutic and toxic doses is narrow. vitamin d resistant rickets: 12,000 to 500,000 usp units daily. hypoparathyroidism: 50,000 to 200,000 usp units daily concomitantly with calcium lactate 4 g, six times per day. dosage must be individualized under close medical supervision. calcium intake should be adequate. blood calcium and phosphorus determinations must be made every 2 weeks or more frequently if necessary. x-rays of the bones should be taken every month until condition is corrected and stabilized.
Contraindications:
Contraindications ergocalciferol capsules, usp are contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin d, and hypervitaminosis d.
Adverse Reactions:
Adverse reactions hypervitaminosis d is characterized by effects on the following organ system: renal: impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death. cns: mental retardation. soft tissues: widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs. skeletal: bone demineralization (osteoporosis) in adults occurs concomitantly. decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism) vague aches, stiffness, and weakness. gastrointestinal: nausea, anorexia, constipation. metabolic: mild acidosis, anemia, weight loss. call your doctor for medical advice about side effects. you may report side effects to strides pharma inc. at 1-877-244-9825 or go to www.strides.com
Drug Interactions:
Drug interactions mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin d preparations. administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with ergocalciferol capsules, usp may cause hypercalcemia.
Pediatric Use:
Pediatric use pediatric doses must be individualized (see dosage and administration ).
Geriatric Use:
Geriatric use clinical studies of ergocalciferol capsules, usp did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. other reported clinical experience has not identified differences in responses between the elderly and younger patients. a few published reports have suggested that the absorption of orally administered vitamin d may be attenuated in elderly compared to younger, individuals. in general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Overdosage:
Overdosage the effects of administered vitamin d can persist for two or more months after cessation of treatment. hypervitaminosis d is characterized by: 1. hypercalcemia with anorexia, nausea, weakness, weight loss, vague aches and stiffness, constipation, mental retardation, anemia, and mild acidosis. 2. impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death. 3. widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs. bone demineralization (osteoporosis) in adults occurs concomitantly. 4. decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism). the treatment of hypervitaminosis d with hypercalcemia consists in immediate withdrawal of the vitamin, a low calcium diet, generous intake of fluids, along with symptomatic and supportive treatment. hypercalcemic crisis with dehydration, stupor, coma, and azotemia requires more vigorous treatment. the first step should be hydration of the patient. intravenous saline may quickly and significantly increase urinary calcium excretion. a loop diuretic (furosemide or ethacrynic acid) may be given with the saline infusion to further increase renal calcium excretion. other reported therapeutic measures include dialysis or the administration of citrates, sulfates, phosphates, corticosteroids, edta (ethylenediaminetetraacetic acid), and mithramycin via appropriate regimens. with appropriate therapy, recovery is the usual outcome when no permanent damage has occurred. deaths via renal or cardiovascular failure have been reported. the ld 50 in animals is unknown. the toxic oral dose of ergocalciferol in the dog is 4 mg/kg.
Description:
Description ergocalciferol capsules, usp are a synthetic calcium regulator for oral administration. ergocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils. it is affected by air and by light. ergosterol or provitamin d 2 is found in plants and yeast and has no antirachitic activity. there are more than 10 substances belonging to a group of steroid compounds, classified as having vitamin d or antirachitic activity. one usp unit of vitamin d 2 is equivalent to one international unit (iu), and 1 mcg of vitamin d 2 is equal to 40 usp units. each capsule contains vitamin d (ergocalciferol) 1.25 mg equivalent to 50,000 usp units in an edible vegetable oil. ergocalciferol, also called vitamin d 2 , is 9,10-secoergosta-5,7,10(19), 22-tetraen-3-ol, (3β,5z,7e,22 e )-; (c 28 h 44 o) with a molecular weight of 396.65, and has the following structural formula: inactive ingredients : fd&c blue #1, fd&c yellow #5, gelatin, glycerin, lecithin, medium chain triglyceride, purified water, shellac glaze, n-butyl alcohol, simethicone, soybean oil and titanium dioxide. vitamin d structure
Clinical Pharmacology:
Clinical pharmacology the in vivo synthesis of the major biologically active metabolites of vitamin d occurs in two steps. the first hydroxylation of ergocalciferol takes place in the liver (to 25-hydroxyvitamin d) and the second in the kidneys (to 1, 25-dihydroxyvitamin d). vitamin d metabolites promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization. vitamin d metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules. there is a time lag of 10 to 24 hours between the administration of vitamin d and the initiation of its action in the body due to the necessity of synthesis of the active metabolites in the liver and kidneys. parathyroid hormone is responsible for the regulation of this metabolism in the kidneys.
How Supplied:
How supplied each capsule contains vitamin d (ergocalciferol) 1.25 mg equivalent to 50,000 usp units. the green colored oval shaped transparent soft gelatin capsules are imprinted with '194' in white and contain clear light yellow oily liquid. bottles of 8 capsules (ndc: 68788-7627-08) bottles of 12 capsules (ndc: 68788-7627-02) bottles of 30 capsules (ndc: 68788-7627-03) bottles of 100 capsules (ndc: 68788-7627-01) store at 20 to 25°c (68 to 77°f) [see usp controlled room temperature]. protect from light. manufactured by: strides pharma science limited bengaluru - 562106, india. distributed by: strides pharma inc. east brunswick, nj 08816 rx only revised: 03/2019 repackaged by preferred pharmaceuticals, inc.
Package Label Principal Display Panel:
Package label.principal display panel ndc 68788-7627 strides pharma inc rx only vitamin d (ergocalciferol capsules, usp) 1.25 mg* (50,000 usp units) warning: do not exceed recommended dosage rx only vitamin d ergocalciferol capsules usp 125mg