cedures should be performed. the following infections will usually respond to adequate dosage of penicillin v. streptococcal infections (without bacteremia) mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. note: streptococci in groups a, c, g, h, l, and m are very sensitive to penicillin. other groups, including group d (enterococcus), are resistant. pneumococcal infections mild to moderately severe infections of the respiratory tract. staphylococcal infections – penicillin g-sensitive mild infections of the skin and soft tissues. note: reports indicate an increasing number of strains of staphylococci resistant to penicillin g, emphasizing the need for culture and sensitivity studies in treating suspected staphylococcal infections. fusospirochetosis (vincent’s gingivitis and pharyngitis) mild to moderately severe infections of the oropharynx usually respond to therapy with oral penicillin. note: necessary dental care should be accomplished in infections involving the gum tissue. medical conditions in which oral penicillin therapy is indicated as prophylaxis: for the prevention of recurrence following rheumatic fever and/or chorea: prophylaxis with oral penicillin on a continuing basis has proven effective in preventing recurrence of these conditions. although no controlled clinical efficacy studies have been conducted, penicillin v has been suggested by the american heart association and the american dental association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients who have congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract1. oral penicillin should not be used in those patients at particularly high risk for endocarditis (e.g., those with prosthetic heart valves or surgically constructed systemic pulmonary shunts). penicillin v should not be used as adjunctive prophylaxis for genitourinary instrumentation or surgery, lower-intestinal tract surgery, sigmoidoscopy, and childbirth. since it may happen that alpha hemolytic streptococci relatively resistant to penicillin may be found when patients are receiving continuous oral penicillin for secondary prevention of rheumatic fever, prophylactic agents other than penicillin may be chosen for these patients and prescribed in addition to their continuous rheumatic fever prophylactic regimen. note: when selecting antibiotics for the prevention of bacterial endocarditis, the physician or dentist should read the full joint statement of the american heart association and the american dental association1.

d diarrhea (cdad) has been reported with use of nearly all antibacterial agents, including penicillin v potassium tablets, and may range in severity from mild diarrhea to fatal colitis. treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of c. difficile. c. difficile produces toxins a and b which contribute to the development of cdad. hypertoxin producing strains of c. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. cdad must be considered in all patients who present with diarrhea following antibiotic use. careful medical history is necessary since cdad has been reported to occur over two months after the administration of antibacterial agents. if cdad is suspected or confirmed, ongoing antibiotic use not directed against c. difficile may need to be discontinued. appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of c. difficile, and surgical evaluation should be instituted as clinically indicated.

ons: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours. for the prevention of recurrence following rheumatic fever and/or chorea: 125 mg to 250 mg (200,000 to 400,000 units) twice daily on a continuing basis. for prophylaxis against bacterial endocarditis1 in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when undergoing dental procedures or surgical procedures of the upper respiratory tract: 2 gram of penicillin v (1 gram for children under 60 lbs.) 1 hour before the procedure, and then, 1 gram (500 mg for children under 60 lbs.) 6 hours later.

omach. average blood levels are two to five times higher than the levels following the same dose of oral penicillin g and also show much less individual variation. once absorbed, penicillin v is about 80% bound to serum protein. tissue levels are highest in the kidneys, with lesser amounts in the liver, skin, and intestines. small amounts are found in all other body tissues and the cerebrospinal fluid. the drug is excreted as rapidly as it is absorbed in individuals with normal kidney function; however, recovery of the drug from the urine indicates that only about 25% of the dose given is absorbed. in neonates, young infants, and individuals with impaired kidney function, excretion is considerably delayed. microbiology susceptibility testing diffusion techniques quantitative methods that require measurement of zone diameters provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. one such standardized procedure2,4 which has been recommended for use with disks to test susceptibility of organisms to penicillin uses the 10 unit (u) penicillin disk. interpretation involves the correlation of the diameters obtained in the disk test with the minimum inhibitory concentration (mic) for penicillin. reports from the laboratory providing results of the standard single-disk susceptibility test with a 10 u penicillin disk should be interpreted according to the criteria provided in table 1. dilution techniques quantitative methods that are used to determine minimum inhibitory concentrations (mics) provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. one such standardized procedure3,4 uses a standardized dilution method (broth or agar) or equivalent with penicillin powder. the mic values obtained should be interpreted according to the criteria provided in table 1. table 1: susceptibility test interpretive criteria pathogen susceptibility test result interpretive criteria disk diffusion (zone diameter in mm) minimal inhibitory concentration (mic in mcg/ml) s i r s i r staphylococcus spp. ≥29 - ≤28 ≤0.12 - ≥0.25 streptococcus spp. (beta-hemolytic group) ≥24 - - ≤0.12 - - streptococcus pneumoniae (non-meningitis isolates) ≤0.06 0.12 to 1 ≥2 a report of “susceptible” indicates that the pathogen is likely to be inhibited by usually achievable concentrations of the antimicrobial compound in the blood. a report of “intermediate” (i) indicates that the result should be considered equivocal, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. this category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of the drug can be used. this category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. a report of “resistant” indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected. quality control standardized susceptibility test procedures require the use of laboratory control microorganisms2,3,4. the 10 u penicillin disk and the standard penicillin powder should provide respectively the following zone diameters and mic values in these laboratory test quality control strains: table 2: acceptable quality control ranges microorganism acceptable quality control ranges disk diffusion (zone diameter ranges in mm) minimal inhibitory concentration range (mic in mcg/ml) staphylococcus aureus atcc® 25923 26 to 37 staphylococcus aureus atcc® 29213 0.25 to 2 streptococcus pneumoniae atcc®49619 24 to 30 0.25 to 1