Product Elements:
Chlordiazepoxide hydrochloride chlordiazepoxide hydrochloride chlordiazepoxide hydrochloride chlordiazepoxide starch, corn lactose monohydrate talc methylparaben propylparaben potassium sorbate d&c yellow no. 10 fd&c blue no. 1 fd&c green no. 3 fd&c yellow no. 6 fd&c red no. 40 titanium dioxide gelatin green;black s252;s chlordiazepoxide hydrochloride chlordiazepoxide hydrochloride chlordiazepoxide hydrochloride chlordiazepoxide starch, corn lactose monohydrate talc methylparaben propylparaben potassium sorbate d&c yellow no. 10 fd&c green no. 3 titanium dioxide gelatin green;white s253;s
Indications and Usage:
Indications and usage chlordiazepoxide hydrochloride capsule is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. the effectiveness of chlordiazepoxide hydrochloride capsule in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. the physician should periodically reassess the usefulness of the drug for the individual patient.
Warnings:
Warnings chlordiazepoxide hydrochloride may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a vehicle or operating machinery. similarly, it may impair mental alertness in children. the concomitant use of alcohol or other central nervous system depressants may have an additive effect. patients should be warned accordingly. usage in pregnancy: an increased risk of congenital malformations associated with the use of minor tranquilizers (chlordiazepoxide, diazepam and meprobamate) during the first trimester of pregnancy has been suggested in several studies. because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. the possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. patients should be advised that if they become pregnant during therapy or intend to become pregnant they should comm
Read more...unicate with their physicians about the desirability of discontinuing the drug. withdrawal symptoms of the barbiturate type have occurred after the discontinuation of benzodiazepines. (see drug abuse and dependence section.)
Dosage and Administration:
Dosage and administration because of the wide range of clinical indications for chlordiazepoxide hydrochloride capsule the optimum dosage varies with the diagnosis and response of the individual patient. the dosage, therefore, should be individualized for maximum beneficial effects. adults usual daily dose relief of mild and moderate anxiety disorders and symptoms of anxiety 5 mg or 10 mg, 3 or 4 times daily relief of severe anxiety disorders and symptoms of anxiety 20 mg or 25 mg, 3 or 4 times daily geriatric patients, or in the presence of debilitating disease. 5 mg, 2 to 4 times daily preoperative apprehension and anxiety: on days preceding surgery, 5 to 10 mg orally, 3 or 4 times daily. if used as preoperative medication, 50 to 100 mg im* 1 hour prior to surgery. pediatric patients usual daily dose because of the varied response of pediatric patients to cns-acting drugs, therapy should be initiated with the lowest dose and increased as required. since clinical experience in pediatr
Read more...ic patients under 6 years of age is limited, the use of the drug in this age group is not recommended. 5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily) for the relief of withdrawal symptoms of acute alcoholism, the parenteral form* is usually used initially. if the drug is administered orally, the suggested initial dose is 50 to 100 mg, to be followed by repeated doses as needed until agitation is controlled - up to 300 mg per day. dosage should then be reduced to maintenance levels. *see package insert for injectable. chlordiazepoxide hydrochloride.
Contraindications:
Contraindications chlordiazepoxide hydrochloride capsule is contraindicated in patients with known hypersensitivity to the drug.
Adverse Reactions:
Adverse reactions the necessity of discontinuing therapy because of undesirable effects has been rare. drowsiness, ataxia and confusion have been reported in some patients - particularly the elderly and debilitated. while these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. in a few instances syncope has been reported. other adverse reactions reported during therapy include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extra pyramidal symptoms, as well as increased and decreased libido. such side effects have been infrequent, and are generally controlled with reduction of dosage. changes in eeg patterns (low-voltage fast activity) have been observed in patients during and after chlordiazepoxide hydrochloride treatment. blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during the
Read more...rapy. when chlordiazepoxide hydrochloride treatment is protracted, periodic blood counts and liver function tests are advisable. to report suspected adverse reactions, contact avkare, inc. at 1-855-361-3993; email drugsafety@avkare.com ; or fda at 1-800-fda-1088 or www.fda.gov/medwatch.
Overdosage:
Overdosage manifestations of chlordiazepoxide hydrochloride overdosage include somnolence, confusion, coma and diminished reflexes. respiration, pulse and blood pressure should be monitored, as in all cases of drug overdosage, although, in general, these effects have been minimal following chlordiazepoxide hydrochloride overdosage. general supportive measures should be employed, along with immediate gastric lavage. intravenous fluids should be administered and an adequate airway maintained. hypotension may be combated by the use of levophed® (norepinephrine) or aramine (metaraminol). dialysis is of limited value. there have been occasional reports of excitation in patients following chlordiazepoxide hydrochloride overdosage; if this occurs barbiturates should not be used. as with the management of intentional overdosage with any drug, it should be borne in mind that multiple agents may have been ingested. flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. the prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in longterm benzodiazepine users and in cyclic antidepressant overdose. the complete flumazenil package insert, including contraindications , warnings and precautions , should be consulted prior to use.
Description:
Description chlordiazepoxide hydrochloride capsules, usp, the original chlordiazepoxide hydrochloride and prototype for the benzodiazepine compounds, was synthesized and developed at hoffmann-la roche inc. it is a versatile therapeutic agent of proven value for the relief of anxiety. chlordiazepoxide hydrochloride capsule is among the safer of the effective psychopharmacologic compounds available, as demonstrated by extensive clinical evidence. chlordiazepoxide hydrochloride is available as capsules containing 5 mg, 10 mg or 25 mg chlordiazepoxide hydrochloride. each capsule also contains corn starch, lactose monohydrate and talc. gelatin capsule shells may contain methyl and propyl parabens, titanium dioxide, gelatin and potassium sorbate, with the following dye systems: 5-mg capsules - fd and c yellow no. 6 plus d and c yellow no. 10 and fd and c green no. 3. 10-mg capsules - d and c yellow no. 10, fd and c blue no. 1, fd and c green no. 3, fd and c yellow no.6 plus fd and c red no. 40. 25-mg capsules - d and c yellow no. 10 and fd and c green no. 3. chlordiazepoxide hydrochloride is 7-chloro-2- (methylamino) -5-phenyl-3h-1,4-benzodiazepine 4-oxide hydrochloride. a white to practically white crystalline substance, it is soluble in water. it is unstable in solution and the powder must be protected from light. the molecular weight is 336.22. the structural formula of chlordiazepoxide hydrochloride is as follows: structure
Clinical Pharmacology:
Clinical pharmacology chlordiazepoxide hydrochloride has antianxiety, sedative, appetite-stimulating and weak analgesic actions. the precise mechanism of action is not known. the drug blocks eeg arousal from stimulation of the brain stem reticular formation. it takes several hours for peak blood levels to be reached and the half-life of the drug is between 24 and 48 hours. after the drug is discontinued plasma levels decline slowly over a period of several days. chlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate. animal pharmacology: the drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. hostile monkeys were made tame by oral drug doses which did not cause sedation. chlordiazepoxide hydrochloride revealed a âtamingâ action with the elimination of fear and aggression. the taming eff
Read more...ect of chlordiazepoxide hydrochloride was further demonstrated in rats made vicious by lesions in the septal area of the brain. the drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals. the ld 50 of parenterally administered chlordiazepoxide hydrochloride was determined in mice (72 hours) and rats (5 days), and calculated according to the method of miller and tainter, with the following results: mice, iv, 123±12mg/kg; mice, im, 366±7mg/kg; rats, iv, 120±7 mg/kg; rats, im, greater than 160 mg/kg. effects on reproduction: reproduction studies in rats fed 10, 20 and 80 mg/kg daily and bred through one or two matings showed no congenital anomalies, nor were there adverse effects on lactation of the dams or growth of the newborn. however, in another study at 100 mg/kg daily there was noted a significant decrease in the fertilization rate and a marked decrease in the viability and body weight of offspring which may be attributable to sedative activity, thus resulting in lack of interest in mating and lessened maternal nursing and care of the young. one neonate in each of the first and second matings in the rat reproduction study at the 100 mg/kg dose exhibited major skeletal defects. further studies are in progress to determine the significance of these findings.
How Supplied:
How supplied chlordiazepoxide hydrochloride. capsules are available in the following presentations: 5 mg hard gelatin capsules in bottles of 90 (ndc 42291-210-90), with s251 imprinted on the opaque green cap and solcoâs logo âsâ imprinted on the opaque yellow body. 10 mg hard gelatin capsules in bottles of 90 (ndc 42291-211-90), with s252 imprinted on the opaque black cap and solcoâs logo âsâ imprinted on the opaque green body. 25 mg hard gelatin capsules in bottles of 90 (ndc 42291-212-90), with s253 imprinted on the opaque green cap and solcoâs logo âsâ imprinted on the opaque white body. store at 25°c (77°f); excursions permitted to 15°c â 30°c (59°f â 86°f). manufactured for: avkare, inc. pulaski, tn 38478 mfg. rev. 10/12 av rev. 02/15 (p)
Package Label Principal Display Panel:
Principal display panel ndc 43353-969 - chlordiazepoxide hydrochloride 10mg - rx only bottle label 10mg
Principal display panel ndc 43353-699 - chlordiazepoxide hydrochloride 25mg - rx only bottle label 25 mg