Product Elements:
Zo skin health pigment control program plus hydroquinone hydroquinone zo skin health gentle cleanser water sodium laureth-3 sulfate cocamidopropyl betaine sodium lauroyl oat amino acids glycerin green tea leaf limonene, (+/-)- linalool, (+/-)- sodium chloride butylene glycol ethylhexylglycerin phenoxyethanol fd&c blue no. 1 d&c red no. 33 zo skin health exfoliating polish polyethylene glycol 400 sodium bicarbonate magnesium oxide diethylene glycol monoethyl ether glycerin butylene glycol oleth-20 trihydroxystearin glyceryl monostearate peg-100 stearate mineral oil water .alpha.-tocopherol acetate, dl- tea tree oil soy sterol limonene, (+/-)- linalool, (+/-)- ascorbyl palmitate vitamin a palmitate stearyl glycyrrhetinate tetrahexyldecyl ascorbate medium-chain triglycerides linoleic acid lecithin, soybean phenoxyethanol d&c green no. 6 zo skin health complexion renewal pads alcohol salicylic acid sodium hydroxide glycolic acid phenoxyethanol sodium carbonate edetate disodium anhydrous denatonium benzoate .beta.-citronellol, (r)- .alpha.-hexylcinnamaldehyde linalool, (+/-)- urea barley butylene glycol sodium chloride tert-butyl alcohol pterocarpus soyauxii wood green tea leaf limonene, (+)- water propylene glycol plantago lanceolata leaf phellodendron amurense bark crithmum maritimum zo skin health pigment control creme hydroquinone hydroquinone water ascorbic acid ascorbyl palmitate caprylyl glycol cetyl alcohol chlorphenesin dioscorea villosa tuber edetate disodium anhydrous glycerin glycolic acid phenoxyethanol quillaja saponaria bark smilax aristolochiifolia root sodium hydroxide sodium lauryl sulfate sodium metabisulfite sodium sulfite stearyl alcohol .alpha.-tocopherol acetate yucca schidigera root hydroquinone hydroquinone zo skin health pigment control plus blending creme hydroquinone hydroquinone ascorbic acid ascorbyl palmitate caprylyl glycol cetyl alcohol chlorphenesin dioscorea villosa tuber edetate disodium anhydrous ethylhexyl palmitate glycerin glycolic acid palmitic acid phenoxyethanol phenyl trimethicone quillaja saponaria bark smilax aristolochiifolia root sodium hydroxide sodium lauryl sulfate sodium metabisulfite sodium sulfite stearyl alcohol .alpha.-tocopherol acetate, dl- water yucca schidigera root hydroquinone hydroquinone zo skin health daily power defense pentylene glycol powdered cellulose retinol limonene, (+)- cetostearyl alcohol c12-20 alkyl glucoside lactose, unspecified form anhydrous lactose butylene glycol hypromellose, unspecified palmitoyl tetrapeptide-7 palmitoyl tripeptide-1 caprylyl glycol steareth-20 .alpha.-tocopherol acetate cyclomethicone 5 glycerin cetearyl isononanoate cyclomethicone 6 phenoxyethanol ext. d&c violet no. 2 edetate disodium anhydrous sodium hydroxide ethylhexylglycerin vitamin a palmitate hexylene glycol arabidopsis thaliana ultramarine blue 1,2-hexanediol c14-22 alcohols cetearyl glucoside carbomer homopolymer, unspecified type water
Drug Interactions:
Drug interactions patients are cautioned on concomitant use of medications that are known to be photosensitizing.
Drug interactions patients are cautioned on concomitant use of medications that are known to be photosensitizing.
Indications and Usage:
Indications and usage pigment control creme is indicated in the gradual bleaching of hyperpigmentation, skin conditions such as chloasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation.
Indications and usage for the gradual bleaching of hyperpigmented skin conditions such as cholasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation.
Warnings:
Warnings hydroquinone is a skin bleaching agent which may produce undesired effects if not used as directed. the physician should be familiar with the contents of this insert before prescribing or dispensing this product. contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. the overall prevalence of sulfite sensitivity in the general population is unknown and probably low. sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people. avoid unnecessary sun exposure, use an effective broad-spectrum sunscreen agent or protective clothing should be worn to cover bleached skin to prevent re-pigmentation from occurring. hydroquinone may produce exogenous ochronosis, a gradual blue-black darkening of the skin. if this condition occurs, discontinue treatment and consult your physician. avoid contact with eyes and mucous membra
Read more...nes. keep out of reach of children. in case of accidental ingestion, call a physician or a poison control center immediately.
Warnings hydroquinone is a skin bleaching agent which may produce undesired effects if not used as directed. the physician should be familiar with the contents of this insert before prescribing or dispensing this product. contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. the overall prevalence of sulfite sensitivity in the general population is unknown and probably low. sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people. avoid unnecessary sun exposure, use an effective broad-spectrum sunscreen agent or protective clothing should be worn to cover bleached skin to prevent re-pigmentation from occurring. hydroquinone may produce exogenous ochronosis, a gradual blue-black darkening of the skin. if this condition occurs, discontinue treatment and consult your physician. avoid contact with eyes and mucous membra
Read more...nes. keep out of reach of children. in case of accidental ingestion, call a physician or a poison control center immediately.
Dosage and Administration:
Drug dosage and administration a thin layer of pigment control creme (hydroquinone usp, 4%) should be applied to the affected area twice daily or as directed by a physician. if no improvement is seen after 8-12 weeks of treatment, use of this product should be discontinued. there is no recommended dosage for pediatric patients under 12 years of age except under the advice and supervision of a physician.
Drug dosage and administration a thin application of pigment control + blending creme should be applied to the affected area twice daily or as directed by a physician. consult product label for instructions on whether to rub in or not. there is no recommendation for children under 12 years of age except under the advice and supervision of a physician.
Contraindications:
Contraindications prior history of sensitivity or allergic reaction to this product or any of its ingredients. the safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established.
Contraindications prior history of sensitivity or allergic reaction to hydroquinone or to any other ingredient in this product. the safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established.
Adverse Reactions:
Adverse reactions the following reactions have been reported: dryness and fissuring of paranasal and infraorbital areas, erythema, and stinging. occasional hypersensitivity (localized contact dermatitis) may develop. if this occurs, the medication should be discontinued, and the physician notified immediately.
Adverse reactions the following reactions have been reported: dryness and fissuring of paranasal and infraorbital areas, erythema, and stinging. occasional hypersensitivity (localized contact dermatitis) may develop. if this occurs, the medication should be discontinued, and the physician notified immediately.
Drug Interactions:
Drug interactions patients are cautioned on concomitant use of medications that are known to be photosensitizing.
Drug interactions patients are cautioned on concomitant use of medications that are known to be photosensitizing.
Use in Pregnancy:
Pregnancy category c animal reproduction studies have not been conducted with topical hydroquinone. it is also not known whether topical hydroquinone can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. topical hydroquinone should be given to a pregnant woman only if clearly needed.
Pregnancy category c animal reproduction studies have not been conducted with topical hydroquinone. it is also not known whether topical hydroquinone can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. topical hydroquinone should be given to a pregnant woman only if clearly needed.
Pediatric Use:
Pediatric use safety and effectiveness for pediatric patients below the age of 12 years have not been established.
Pediatric use safety and effectiveness for pediatric patients below the age of 12 years have not been established.
Overdosage:
Overdosage there have been no system reactions reported from the use of topical hydroquinone. however, treatment should be limited to relatively small areas of the body at one time, since some patients experience a transient skin reddening and a mild burning sensation which does not preclude treatment.
Overdosage there have been no system reactions reported from the use of topical hydroquinone. however, treatment should be limited to relatively small areas of the body at one time, since some patients experience a transient skin reddening and a mild burning sensation which does not preclude treatment.
Description:
Description hydroquinone is 1,4-benzendiol, with a chemical formula of c6h6o2 and a molecular weight of 110.11. the structural formula is: each gram of pigment control creme (hydroquinone usp, 4%) contains hydroquinone usp 40 mg/gm in a base of purified water, ascorbic acid, ascorbyl palmitate, beta-glucan, caprylyl glycol, cetyl alcohol, chlorphenesin, dioscorea villosa (wild yam) root extract, disodium edta, glycerin, glycolic acid, phenoxyethanol, quillaja saponaria bark extract, smilax aristolochiifolia root extract, sodium hydroxide, sodium lauryl sulfate, sodium metabisulfite, sodium sulfite, stearyl alcohol, tocopheryl acetate, yucca schidigera root extract. chemical structure
Description hydroquinone is 1,4-benzendiol, with a chemical formula of c6h6o2 and a molecular weight of 110.11. the structural formula is: each gram of pigment control + blending creme contains hydroquinone usp 40mg/gm in a base of ascorbic acid, ascorbyl palmitate, beta-glucan, caprylyl glycol, cetyl alcohol, chlorphenesin, dioscorea villosa (wild yam) root extract, disodium edta, ethylhexyl palmitate, glycerin, glycolic acid, palmitic acid, phenoxyethanol, phenyl trimethicone, purified water, quillaja saponaria bark extract, smilax aristolochiifolia root extract, sodium hydroxide, sodium lauryl sulfate, sodium metabisulfite, sodium sulfite, stearyl alcohol, tocopheryl acetate, yucca schidigera root extract. chemical structure
Clinical Pharmacology:
Clinical pharmacology topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine (dopa) and suppression of other melanocyte metabolic processes. exposure to sunlight or ultraviolet light will cause re-pigmentation of bleached areas, which may be prevented by the use of the sunscreen agents.
Clinical pharmacology topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine (dopa) and suppression of other melanocyte metabolic processes. exposure to sunlight or ultraviolet light will cause re-pigmentation of bleached areas, which may be prevented by the use of the sunscreen agents.
Carcinogenesis and Mutagenesis and Impairment of Fertility:
Carcinogenesis, mutagenesis, impairment of fertility studies of hydroquinone in animals have demonstrated some evidence of carcinogenicity. the carcinogenic potential of hydroquinone in humans is unknown.
Carcinogenesis, mutagenesis, impairment of fertility studies of hydroquinone in animals have demonstrated some evidence of carcinogenicity. the carcinogenic potential of hydroquinone in humans is unknown.
How Supplied:
How supplied pigment control creme (hydroquinone usp, 4%) is available as follows: 2.7 fl. oz. (80 ml) bottle / ndc 42851-037-80 1.0 fl oz/30 ml bottle / ndc 42851-037-30 storage store at controlled room temperature: 15°-30°c (59°-86°f)
How supplied pigment control + blending creme (hydroquinone usp, 4%) is available as follows: 2.7 fl. oz. (80 ml) bottle / ndc 42851-036-80 1.0 fl. oz (30 ml) bottle / ndc 42851-036-30 storage store at controlled room temperature: 15°-30°c (59°-86°f)
Package Label Principal Display Panel:
Principal display panel - kit carton zo ® skin health by zein obagi md pigment control program + hydroquinone ndc 42851-184-60 gentle cleanser 60 ml / 2 fl. oz. exfoliating polish net wt. 16.2 g / 0.57 oz. complexion renewal pads 30 pads pigment control crÃme 30 ml / 1.0 fl. oz. daily power defense 30 ml / 1 fl. oz. pigment control + blending creme 30 ml / 1 fl. oz. us pigment control + hydroquinone kit uc.jpg