s tachycardia, palpitations, premature ventricular contractions, atrial flutter, atrial fibrillation, ventricular flutter, ventricular fibrillation, cardiac syncope, asystole, and myocardial infarction [see adverse reactions ( 6 )] . in patients with a recent myocardial infarction and/or severe coronary artery disease, there is a possibility that atropine-induced tachycardia may cause ischemia, extend or initiate myocardial infarcts, and stimulate ventricular ectopy and fibrillation. atropen should be used with caution in patients with known cardiovascular disease or cardiac conduction problems. 5.2 heat injury atropen may inhibit sweating which, in a warm environment or with excessive exercise, can lead to hyperthermia and heat injury. to the extent feasible, avoid excessive exercise and heat exposure [see adverse reactions ( 6 ), overdosage ( 10 )] . 5.3 acute glaucoma atropen may cause acute glaucoma and should be administered with caution in patients at risk for acute glaucoma or who have severe narrow angle glaucoma. monitor for signs and symptoms of intraocular pressure, as appropriate. 5.4 urinary retention atropen may cause urinary retention and should be administered with caution to patients with clinically significant bladder outflow obstruction. 5.5 pyloric stenosis atropen may cause complete pyloric obstruction in patients with partial pyloric stenosis. these patients should be monitored for gastrointestinal symptoms following administration of atropen. 5.6 exacerbation of chronic lung disease atropine may cause thickening of bronchial secretions and formation of dangerous viscid plugs in individuals with chronic lung disease. respiratory status should be monitored in individuals with chronic lung disease following administration of atropen. 5.7 hypersensitivity atropine can cause hypersensitivity reactions, including anaphylactic reactions [see adverse reactions ( 6 )] . medical supervision is necessary in patients who have had previous anaphylactic reactions to atropine and require treatment for organophosphorus or nerve agent poisoning.

or mild symptoms plus two (2) more for severe symptoms [see dosage and administration ( 2.2 )] . different dose strengths of atropen are available depending on the patient's weight. atropen should be used by persons who have had adequate training in the recognition and treatment of nerve agent or insecticide intoxication, but may be administered by a caregiver or self-administration if a trained provider is not available. only administer atropen to patients experiencing symptoms of organophosphorus or carbamate poisoning in a situation where exposure is known or suspected. atropen is a single-dose autoinjector intended as an initial treatment of the muscarinic symptoms of insecticide or nerve agent poisonings (generally breathing difficulties due to increased secretions); definitive medical care should be sought immediately. atropen should be administered as soon as symptoms of organophosphorus or carbamate poisoning appear. in severe poisonings, it may also be desirable to concurrently administer an anticonvulsant (preferably a benzodiazepine) if seizure is suspected in the unconscious individual since the classic tonic-clonic jerking may not be apparent due to the effects of the poison. a cholinesterase reactivator such as pralidoxime may serve as an important adjunct to atropine therapy. close supervision of all treated patients is indicated for at least 48 to 72 hours. parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit [see dosage forms and strengths ( 3 )] . 2.2 dosage information different dose strengths of atropen are available depending on the patient's age and weight (see table 1 ). table 1: recommended dose strength per atropen injection age and body weight strength of each atropen injection adults and pediatric patients weighing over 41 kg (90 pounds) (generally over 10 years of age) atropen 2 mg (green label) pediatric patients weighing 18 kg to 41 kg (40 pounds to 90 pounds) (generally 4 to 10 years of age) atropen 1 mg (red label) pediatric patients weighing 7 kg to 18 kg (15 pounds to 40 pounds) (generally 6 months to 4 years of age) atropen 0.5 mg (blue label) pediatric patients weighing less than 7 kg (15 pounds) (generally less than 6 months of age) atropen 0.25 mg (yellow label) dosage for mild symptoms first dose: if the patient experiences two or more mild symptoms of nerve agent or insecticide exposure listed in table 2 , administer one (1) atropen injection intramuscularly into the mid-lateral (outer) thigh. additional doses: if, at any time after receiving the first atropen injection, the patient has any of the severe symptoms listed in table 2 , administer two (2) additional atropen injections in rapid succession. if possible, a person other than the patient should administer the second and third atropen injections. wait 10 to 15 minutes for atropen to take effect. if after 10 to 15 minutes, the patient does not develop any of the severe symptoms listed in table 2 , no additional atropen injections are recommended. dosage for severe symptoms if the patient is either unconscious or has any of the severe symptoms listed in table 2 , immediately administer three (3) atropen injections intramuscularly into the patient's mid-lateral thigh in rapid succession. table 2: common symptoms of organophosphorus or carbamate poisoning * these symptoms are sometimes observed in healthy infants and young children. in this age group, these symptoms are less reliable than other symptoms listed. symptoms must be considered collectively when nerve agent or pesticide exposure is known or suspected. ** infants may become drowsy or unconscious, with muscle floppiness rather than muscle twitching, soon after exposure to nerve agents or insecticides. mild symptoms severe symptoms blurred vision, miosis excessive, unexplained teary eyes* excessive, unexplained runny nose* increased salivation such as sudden unexplained excessive drooling* chest tightness or difficulty breathing tremors throughout the body or muscular twitching nausea and/or vomiting unexplained wheezing, coughing or increased airway secretions acute onset of stomach cramps tachycardia or bradycardia strange or confused behavior severe difficulty breathing or copious secretions from lungs/airway severe muscular twitching and general weakness** involuntary urination and defecation* convulsions unconsciousness 2.3 administration instructions directions for the use of 2 mg, 1 mg, and 0.5 mg atropen snap the grooved end of the plastic sleeve down and over the yellow safety release. remove the atropen autoinjector from the plastic sleeve. do not place fingers on the green tip. firmly grasp the atropen autoinjector with the green tip (needle end) pointed down. with your other hand, pull off the yellow safety release. atropen is now ready to be administered. aim and firmly jab the green tip straight down (at a 90° angle) against the mid-lateral thigh. the atropen device will activate and deliver the medicine when you do this. atropen can inject through clothing, but make sure pockets at the injection site are empty. very thin people and small children should also be injected in the mid-lateral thigh, but before giving atropen, bunch up the thigh to provide a thicker area for injection. hold the atropen autoinjector firmly in place for at least 10 seconds to allow the injection to finish. remove the atropen autoinjector and massage the injection site for several seconds. if the needle is not visible, check to be sure the yellow safety release has been removed, and repeat steps 4 and 5, but press harder. after use, using a hard surface, bend the needle back against the atropen autoinjector and either pin the used atropen autoinjectors to the patient's clothing or show the used atropen autoinjectors to the first medical person you see. this will allow medical personnel to see the number and dose of atropen autoinjectors administered. move yourself and the patient away from the contaminated area right away. try to find medical help. directions for the use of 0.25 mg atropen remove the plastic cap from the yellow tube and slide the atropen autoinjector from the tube. do not place fingers on the black tip. firmly grasp the atropen autoinjector with the black tip (needle end) pointed down. with your other hand, pull off the gray safety release. atropen is now ready to be administered. bunch up the thigh to provide a thicker area for injection. aim and firmly jab the black tip straight down (at a 90° angle) against the mid-lateral thigh. the atropen device will activate and deliver the medicine when you do this. hold the atropen autoinjector firmly in place for at least 10 seconds to allow the injection to finish. remove the atropen autoinjector and massage the injection site for several seconds. if the needle is not visible, check to be sure the gray safety release has been removed, and repeat steps 4 and 5, but press harder. after use, using a hard surface, bend the needle back against the atropen autoinjector and either pin the used atropen autoinjectors to the patient's clothing or show the used atropen autoinjectors to the first medical person you see. this will allow medical personnel to see the number and dose of atropen autoinjectors administered. move yourself and the patient away from the contaminated area right away. try to find medical help.

ache, dizziness, tachycardia, palpitations, flushing, urinary hesitance or retention, constipation, abdominal pain, abdominal distention, nausea, vomiting, loss of libido, and impotency. ( 6 ) to report suspected adverse reactions, contact meridian medical technologies ® , llc at 1-833-739-0945 or fda at 1-800-fda-1088 or www.fda.gov/medwatch. adverse reactions at recommended doses common adverse reactions of atropine can be attributed to its antimuscarinic action. these include dryness of the mouth, blurred vision, dry eyes, photophobia, confusion, headache, dizziness, tachycardia, palpitations, flushing, urinary hesitancy or retention, constipation, abdominal pain, abdominal distention, nausea and vomiting, loss of libido, and impotence. anhidrosis may produce heat intolerance and impairment of temperature regulation in a hot environment. dysphagia, paralytic ileus, acute angle closure glaucoma, maculopapular rash, petechial rash, and scarlatiniform rash have also been reported. adverse cardiac reactions, including arrhythmias and myocardial infarction, have been reported with atropine [see warnings and precautions ( 5.1 ), clinical pharmacology ( 12.2 )]. larger doses of atropine may produce central nervous system effects such as restlessness, tremor, fatigue, locomotor difficulties, delirium, hallucinations, depression and ultimately, medullary paralysis and death [see overdosage ( 10 )] . large doses can also lead to circulatory collapse. in such cases, blood pressure declines and death due to respiratory failure may ensue following paralysis and coma. hypersensitivity hypersensitivity reactions will occasionally occur with atropine; these are usually seen as skin rashes and may progress to exfoliation. anaphylactic reaction and laryngospasm have also occurred. pediatric patients adverse events seen in pediatrics are similar to those that occur in adult patients although central nervous system complaints are often seen earlier and at lower doses. additional adverse reactions to atropine by organ system the following adverse reactions were reported in published literature for atropine in both adults and children: cardiovascular : sinus tachycardia, supraventricular tachycardia, junctional tachycardia, ventricular tachycardia, bradycardia, palpitations, ventricular arrhythmia, ventricular flutter, ventricular fibrillation, atrial arrhythmia, atrial fibrillation, atrial ectopic beats, ventricular premature contractions, bigeminal beats, trigeminal beats, nodal extrasystole, ventricular extrasystole, supraventricular extrasystole, asystole, cardiac syncope, prolongation of sinus node recovery time, cardiac dilation, left ventricular failure, myocardial infarction, intermittent nodal rhythm (no p wave), prolonged p wave, shortened pr segment, r on t phenomenon, shortened rt duration, widening and flattening of qrs complex, prolonged qt interval, flattening of t wave, repolarization abnormalities, altered st-t waves, retrograde conduction, transient atrioventricular (av) dissociation, increased blood pressure, decreased blood pressure, labile blood pressure, weak or impalpable peripheral pulses. eye : mydriasis, blurred vision, pupils poorly reactive to light, photophobia, decreased contrast sensitivity, decreased visual acuity, decreased accommodation, cycloplegia, strabismus, heterophoria, cyclophoria, acute angle closure glaucoma, conjunctivitis, keratoconjunctivitis sicca, blindness, tearing, dry eyes/dry conjunctiva, irritated eyes, crusting of eyelid, blepharitis. gastrointestinal : nausea, abdominal pain, paralytic ileus, decreased bowel sounds, distended abdomen, vomiting, delayed gastric emptying, decreased food absorption, dysphagia. general : hyperpyrexia, lethargy, somnolence, chest pain, excessive thirst, weakness, syncope, insomnia, tongue chewing, dehydration, feeling hot, injection site reaction. immunologic : anaphylactic reaction. special investigations : leukocytosis, hyponatremia, elevated blood urea nitrogen (bun), elevated hemoglobin, elevated erythrocytes, low hemoglobin, hypoglycemia, hyperglycemia, hypokalemia, increase in photic stimulation on electroencephalogram (eeg), signs of drowsiness on eeg, runs of alpha waves on eeg, alpha waves (eeg) blocked upon opening eyes. metabolic : failure to feed. central nervous system : ataxia, hallucinations (visual or aural), seizures (generally tonic-clonic), abnormal movements, coma, confusion, stupor, dizziness, amnesia, headache, diminished tendon reflexes, hyperreflexia, muscle twitching, opisthotonos, babinski's reflex/chaddock's reflex, hypertonia, dysmetria, muscle clonus, sensation of intoxication, difficulty concentrating, vertigo, dysarthria. psychiatric : agitation, restlessness, delirium, paranoia, anxiety, mental disorders, mania, withdrawn behavior, behavior changes. genitourinary : difficulty in micturition, urine urgency, distended urinary bladder, urine retention, bed-wetting. pulmonary : tachypnea, slow respirations, shallow respirations, breathing difficulty, labored respirations, inspiratory stridor, laryngitis, laryngospasm, pulmonary edema, respiratory failure, subcostal recession. dermatologic : dry mucous membranes, dry warm skin, flushed skin, oral lesions, dermatitis, petechiae, rash, macular rash, papular rash, maculopapular rash, scarlatiniform rash, erythematous rash, sweating/moist skin, cold skin, cyanosed skin, salivation. injection site muscle tightness and pain may occur at the injection site. inadvertent injection in cases where atropen is inadvertently administered to people who are not poisoned with nerve agent or organophosphorus insecticide, the following effects on their ability to function normally may occur. patients with cardiac disease may be at risk for serious adverse events, including death. atropine 2 mg im, when given to healthy male volunteers, is associated with minimal effects on visual, motor, and mental functions, though unsteadiness walking and difficulty concentrating may occur. atropine reduces body sweating and increases body temperature, particularly with exercise and under hot conditions. atropine 4 mg im, when given to healthy male volunteers, is associated with impaired visual acuity, visual near point accommodation, logical reasoning, digital recall, learning, and cognitive reaction time. ability to read is reduced or lost. subjects are unsteady and need to concentrate on walking. these effects begin about 15 minutes to one hour or more post-dose. atropine 6 mg im, when given to healthy male volunteers, is associated with the effects described above plus additional central nervous system effects including poor coordination, poor attention span, and visual hallucinations (colored flashes) in many subjects. frank visual hallucinations, auditory hallucinations, disorientation, and ataxia occur in some subjects. skilled and labor-intense tasks are performed more slowly and less efficiently. decision making takes longer and is sometimes impaired. it is unclear if the above data, obtained from studies of healthy adult subjects, can be extrapolated to other populations. in the elderly and patients with co-morbid conditions, the effects of ≥2 mg atropine on the ability to see, walk, and think properly are unstudied; effects may be greater in susceptible populations. patients who are mistakenly injected with atropen should avoid potentially dangerous overheating, avoid vigorous physical activity, and seek medical attention as soon as feasible. adverse reactions observed in pediatric patients after inappropriate administration of atropen amitai et el (jama 1990) evaluated the safety of atropen 0.5 mg, 1 mg, and 2 mg in a case series of 240 children who received atropen inappropriately (i.e., no nerve agent exposure) during the 1990 gulf war period. overall, severity of atropinization followed a nonlinear correlation with dose. estimated doses up to 0.045 mg/kg produced no signs of atropinization. estimated doses between 0.045 mg/kg to 0.175 mg/kg and even greater than 0.175 mg/kg were associated with mild and severe effects, respectively. actual dosage received by children may have been considerably lower than estimated since incomplete injection in many cases was suspected. regardless, adverse events reported were generally mild and self-limited. few children required hospitalization. adverse reactions reported were dilated pupils (43%), tachycardia (39%), dry membranes (35%), flushed skin (20%), temperature 37.8°c or 100°f (4%), and neurologic abnormalities (5%). there was also local pain and swelling. in 91 children with electrocardiograms (ecgs), no abnormalities were noted other than sinus tachycardia; 22 children had severe tachycardia of 160 bpm to 190 bpm. neurologic abnormalities consisted of irritability, agitation, confusion, lethargy, and ataxia

ernal condition. 8.4 pediatric use a review of published literature supports the safety and effectiveness of atropine in the setting of organophosphate insecticide poisoning in all pediatric age groups. adverse events seen in pediatric patients treated with atropine are similar to those that occur in adult patients, although central nervous system effects are often seen earlier and at lower doses [see adverse reactions ( 6 )]. overheating (atropine fever) caused by suppression of sweat gland activity may be more pronounced in infants and small children. extreme hyperthermia in a newborn has been reported with as little as 0.065 mg orally. 8.5 geriatric use geriatric patients may be more susceptible to the effects of atropine. because of the longer half-life of atropine in geriatric patients, they may require less frequent doses after the initial dose [see clinical pharmacology ( 12.3 )].

creases heart rate and reduces atrioventricular conduction time. adequate atropine doses can prevent or abolish bradycardia or asystole produced by organophosphorus nerve agents. atropine may decrease the degree of partial heart block, which can occur after organophosphorus poisoning. in some patients with complete heart block, atropine may accelerate the idioventricular rate; in others, the rate is stabilized. in some patients with conduction defects, atropine may cause paradoxical atrioventricular block and nodal rhythm. atropine will not act on the neuromuscular junction and has no effect on muscle paralysis or weakness, fasciculations or tremors. atropine is not dependable in reversing the weakness or paralysis of the respiratory muscles. severe difficulty in breathing requires artificial respiration in addition to the use of atropine. systemic doses of atropine slightly raise systolic and lower diastolic pressures and can produce significant postural hypotension. such doses also slightly increase cardiac output and decrease central venous pressure. atropine can dilate cutaneous blood vessels, particularly the “blush” area (atropine flush), may cause atropine “fever” due to suppression of sweat gland activity especially in infants and small children and may inhibit sweating, thereby causing hyperthermia, particularly in a warm environment or with exercise [see warnings and precautions ( 5.2 )]. 12.3 pharmacokinetics atropine is well absorbed after intramuscular administration. following 1.67 mg atropine given intramuscularly to adults by the 2 mg atropen delivery system, the peak concentration (c max ) is 9.6 ± 1.5 (mean ± sem) ng/ml reached between 3-60 minutes (t max ). the protein binding of atropine is 14 to 22% in plasma. atropine is distributed throughout the various body tissues and fluids. much of the drug is metabolized by enzymatic hydrolysis, particularly in the liver. atropine has been reported to be excreted in human milk [see use in specific populations ( 8.2 )] . the unchanged drug excreted by urine is approximately 13 to 50%. specific populations gender the auc (0-inf) and c max values for atropine are 15% higher in females than males. the half-life of atropine is approximately 20 minutes shorter in females than males. geriatric the half-life of intravenous atropine is 3.0 ± 0.9 (mean ± sd) hours in adults and 10.0 ± 7.3 (mean ± sd) hours in geriatric patients (65 to 75 years of age). pediatric the half-life of intravenous atropine in pediatric subjects under 2 years is 6.9 ± 3.3 (mean ± sd) hours; in children over 2 years, the half-life is 2.5 ± 1.2 (mean ± sd) hours. renal and hepatic impairment the pharmacokinetics of atropine has not been evaluated in subjects with renal or hepatic impairment.

geriatric patients (65 to 75 years of age). pediatric the half-life of intravenous atropine in pediatric subjects under 2 years is 6.9 ± 3.3 (mean ± sd) hours; in children over 2 years, the half-life is 2.5 ± 1.2 (mean ± sd) hours. renal and hepatic impairment the pharmacokinetics of atropine has not been evaluated in subjects with renal or hepatic impairment.

ºf); excursions permitted between 15ºc and 30ºc (between 59ºf and 86ºf) [see usp controlled room temperature]. not made with natural rubber latex. keep from freezing. protect from light. after the atropen autoinjector has been activated, the empty container should be disposed of properly. it cannot be refilled, nor can the protruding needle be retracted.

e physical activity since atropine can inhibit sweating which can lead to overheating and heat injury. manufactured by: meridian medical technologies ® , llc st. louis, mo 63146

o 10 years of age) 1 mg atropen (red label) 1 mg children weighing 15 pounds to 40 pounds (7 kg to 18 kg) (generally 6 months to 4 years of age) 0.5 mg atropen (blue label) 0.5 mg infants weighing less than 15 pounds (7 kg) (generally less than 6 months of age) 0.25 mg atropen (yellow label) 0.25 mg caution : when the atropen is activated, the needle will quickly extend from the green tip and black tip. keep your fingers away from the green tip and black tip . step 2 decide if symptoms are mild or severe if nerve agent or insecticide exposure is known or suspected, you may see the following mild and severe symptoms. you may not have all of the symptoms or see all symptoms in others exposed to a nerve agent or certain insecticide poisoning: mild symptoms severe symptoms - blurred vision and sore eyes - excessive, unexplained teary eyes - excessive, unexplained runny nose - increase saliva or sudden drooling - chest tightness or breathing problems - shaking (tremors) throughout the body or muscle twitching - nausea and vomiting - unexplained wheezing, coughing or increase in mucus (phlegm) coming from the lungs - sudden stomach cramping - fast heartbeat (tachycardia) or slow heartbeat (bradycardia) - strange or confused behavior - severe breathing problems or a large amount of fluid (secretions) coming from the lungs - severe muscle twitching and general weakness - problems controlling urine or stool (bowel movement) - seizures (convulsions) - passing out (unconsciousness) symptoms in infants and young children: the mild symptoms excessive, unexplained teary eyes, excessive, unexplained runny nose and increased saliva or sudden drooling , and the severe symptom problems controlling urine or stool (bowel movement) are sometimes seen in healthy infants and young children. in infants and young children, these symptoms are seen less often than the other mild and severe symptoms listed above. symptoms must be looked at together when nerve agent or insecticide exposure is known or suspected. the severe symptoms severe muscle twitching and general weakness can happen in infants. infants may become drowsy or pass out, with muscle floppiness instead of muscle twitching, soon after exposure to nerve agents or insecticides. step 3 treating mild symptoms first dose: give 1 dose of atropen (1 injection) if you get 2 or more mild symptoms of nerve agent or insecticide exposure. give the injection in the outer thigh. ask a caregiver to check your symptoms to see if they continue or get worse. get medical help right away . additional doses: if, any time after the first injection of atropen, the exposed person gets any of the severe symptoms listed above, give 2 more doses of atropen (2 injections) in the outer thigh quickly one right after the other. use a new atropen for each injection. if you have given yourself the first injection, someone else should give you the second and third atropen injections, if possible. treating severe symptoms if you get any of the severe symptoms of nerve agent or insecticide exposure listed above or you see an exposed person who has passed out (unconscious), give 3 doses of atropen (3 injections) right away . give the 3 injections in the outer thigh quickly, one right after the other, using a new atropen for each injection. get medical help right away . warning : giving more atropen injections by mistake in people who do not have nerve agent or insecticide poisoning may cause an overdose of atropine. this can lead to being unable to see or walk well for several hours. people with heart problems may have serious side effects, that can lead to death. step 4 give the atropen injection instructions for use of 2 mg, 1 mg, and 0.5 mg atropen (see below for 0.25 mg dose instructions) (a) snap the grooved end of the plastic sleeve down and over the yellow safety release. remove the atropen from the plastic sleeve. caution: do not place fingers on the green tip. (b) firmly grasp the atropen in 1 hand with the green tip pointed down. (c) pull off the yellow safety release with your other hand. (d) aim and firmly jab the green tip straight down (at a 90 degree angle) against the outer thigh. the atropen will activate and deliver the medicine. you can inject through clothing, but make sure pockets at the injection site are empty. note: people who do not have a lot of fat at the injection site and small children should also be injected in the outer thigh. before giving the atropen injection, pinch a fold of skin on the outer thigh to provide a thicker area for injection. (e) hold the atropen firmly in place for at least 10 seconds to allow the injection to finish. (f) after 10 seconds, remove the atropen and massage the injection site for several seconds. note: if you see the needle after removing the atropen, the injection is complete. if you do not see the needle, check to make sure the yellow safety release has been removed. if the yellow safety release has been removed, repeat step 4 (d) and step 4 (e), but press harder to activate the atropen. (g) after the injection, bend the needle back against the atropen using a hard surface. use the bent needle as a hook to pin the used atropen to the clothing of the exposed person. you can also show the used atropen to the first medical person you see. this will allow medical personnel to see the number of atropens used and the dose. move yourself and the exposed person away from the contaminated area right away. get medical help right away. instructions for use of 0.25 mg atropen (a) remove the plastic cap from the yellow tube and slide the atropen out of the tube. caution: do not place fingers on the black tip. (b) firmly grasp the atropen in 1 hand with the black tip pointed down. (c) pull off the gray safety release with your other hand. (d) pinch a fold of skin on the outer thigh to provide a thicker area for injection. aim and firmly jab the black tip straight down (at a 90 degree angle) against the outer thigh. the atropen will activate and deliver the medicine. you can inject through clothing, but make sure pockets at the injection site are empty. (e) hold the atropen firmly in place for at least 10 seconds to allow the injection to finish. (f) after 10 seconds, remove the atropen and massage the injection site for several seconds. note: if you see the needle after removing the atropen, the injection is complete. if you do not see the needle, check to make sure the gray safety release has been removed. if the gray safety release has been removed, repeat step 4 (d) and step 4 (e), but press harder to activate the atropen. (g) after the injection, bend the needle back against the atropen using a hard surface. use the bent needle as a hook to pin the used atropen to the clothing of the exposed person. you can also show the used atropen to the first medical person you see. this will allow medical personnel to see the number of atropens used and the dose. move yourself and the exposed person away from the contaminated area right away. get medical help right away. this instructions for use has been approved by the u.s. food and drug administration. atropen ® is a registered trademark of meridian medical technologies ® , llc st. louis, mo 63146 1-833-739-0945 revised: 09/2022 figure figure figure figure figure figure figure figure figure figure figure figure figure figure figure figure figure figure