Product Elements:
Dextrose dextrose monohydrate dextrose monohydrate anhydrous dextrose water dextrose dextrose monohydrate dextrose monohydrate anhydrous dextrose water dextrose dextrose monohydrate dextrose monohydrate anhydrous dextrose water
Indications and Usage:
Indications and usage intravenous solutions containing dextrose are indicated for parenteral replenishment of fluid and minimal carbohydrate calories as required by the clinical condition of the patient.
Warnings:
Warnings excessive administration of potassium-free solutions may result in significant hypokalemia. the intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema. the risk of dilutional states is inversely proportional to the electrolyte concentrations of administered parenteral solutions. the risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of such solutions.
Dosage and Administration:
Dosage and administration the dose is dependent upon the age, weight and clinical condition of the patient. as reported in the literature, the dosage and constant infusion rate of intravenous dextrose must be selected with caution in pediatric patients, particularly neonates and low birth weight infants, because of the increased risk of hyperglycemia/hypoglycemia. drug interactions additives may be incompatible. consult with pharmacist, if available. when introducing additives, use aseptic technique, mix thoroughly and do not store. parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (see precautions .) instructions for use to open: tear outer wrap at notch and remove solution container. if supplemental medication is desired, follow directions below before preparing for administration. to add medication 1. prepare additive port. 2. using aseptic technique and an additive delivery
Read more... needle of appropriate length, puncture resealable additive port at target area, inner diaphragm and inject. withdraw needle after injecting medication. 3. the additive port may be protected by covering with an additive cap. 4. mix container contents thoroughly. preparation for administration (use aseptic technique) 1. close flow control clamp of administration set. 2. remove cover from outlet port at bottom of container. 3. insert piercing pin of administration set into port with a twisting motion until the set is firmly seated. note: when using a vented administration set, replace bacterial retentive air filter with piercing pin cover. insert piercing pin with twisting motion until shoulder of air filter housing rests against the outlet port flange. 4. suspend container from hanger. 5. squeeze and release drip chamber to establish proper fluid level in chamber. 6. attach venipuncture device to set. 7. open clamp to expel air from set and venipuncture device. close clamp. 8. perform venipuncture. 9. regulate rate of administration with flow control clamp. warning: do not use flexible container in series connections.
Contraindications:
Contraindications dextrose injection without electrolytes should not be administered simultaneously with blood through the same infusion set because of the possibility that pseudoagglutination of red cells may occur.
Adverse Reactions:
Adverse reactions reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia. if an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Overdosage:
Overdosage in the event of overhydration or solute overload, re-evaluate the patient and institute appropriate corrective measures. (see warnings , precautions , and adverse reactions .)
Description:
Description dextrose injection, usp solutions are sterile and nonpyrogenic. they are parenteral solutions containing various concentrations of dextrose in water for injection intended for intravenous administration. each 100 ml of 5% dextrose injection, usp, contains dextrose, hydrous 5 g in water for injection. the caloric value is 170 kcal/l. the osmolarity is 252 mosmol/l (calc.), which is slightly hypotonic. each 100 ml of 10% dextrose injection, usp, contains dextrose, hydrous 10 g in water for injection. the caloric value is 340 kcal/l. the osmolarity is 505 mosmol/l (calc.), which is hypertonic. the ph for both concentrations is 4.3 (3.2 to 6.5). the solutions contain no bacteriostat, antimicrobial agent or added buffer and each is intended only as a single-dose injection. when smaller doses are required the unused portion should be discarded. the solutions are parenteral fluid and nutrient replenishers. dextrose, usp is chemically designated d-glucose monohydrate (c 6 h 12 o 6 ⢠h 2 o), a hexose sugar freely soluble in water. it has the following structural formula: water for injection, usp is chemically designated h 2 o. the flexible plastic container is fabricated from a specially formulated polyvinylchloride. water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. exposure to temperatures above 25°c/77°f during transport and storage will lead to minor losses in moisture content. higher temperatures lead to greater losses. it is unlikely that these minor losses will lead to clinically significant changes within the expiration period. structural formula dextrose
Clinical Pharmacology:
Clinical pharmacology when administered intravenously, these solutions provide a source of water and carbohydrate. isotonic and hypertonic concentrations of dextrose are suitable for parenteral maintenance of water requirements when salt is not needed or should be avoided. solutions containing carbohydrate in the form of dextrose restore blood glucose levels and provide calories. carbohydrate in the form of dextrose may aid in minimizing liver glycogen depletion and exerts a protein-sparing action. dextrose injected parenterally undergoes oxidation to carbon dioxide and water. water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. average normal adult daily requirements range from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). water balance is maintained by various regulatory mechanisms. water distribution depends primarily on the concentration of electrolytes in the bo
Read more...dy compartments and sodium (na + ) plays a major role in maintaining physiologic equilibrium.
How Supplied:
How supplied dextrose injection, usp is supplied in single-dose flexible plastic containers in various sizes and concentrations as shown in the accompanying table. icu medical is transitioning ndc codes from "0409" to "0990" labeler code. both ndc codes are expected to be in the market for a period of time. ndc no. product container size (ml) 0409-7922-61 manufactured by icu medical, inc., lake forest, illinois, 60045, usa 5% dextrose injection, usp 150 0990-7922-61 5% dextrose injection, usp 150 0409-7922-53 manufactured for icu medical, inc., lake forest, illinois, 60045, usa 5% dextrose injection, usp 250 0990-7922-53 5% dextrose injection, usp 250 0409-7922-02 5% dextrose injection, usp 250 0990-7922-02 5% dextrose injection, usp 250 0409-7922-03 5% dextrose injection, usp 500 0990-7922-03 , 5% dextrose injection, usp 500 0409-7922-55 5% dextrose injection, usp 500 0990-7922-55 , 5% dextrose injection, usp 500 0409-7922-09 , 5% dextrose injection, usp 1000 0990-7922-09 , 5% dextros
Read more...e injection, usp 1000 0409-7923-20 5% dextrose injection, usp 25 0990-7923-20 5% dextrose injection, usp 25 0409-7923-36 5% dextrose injection, usp 50 0990-7923-36 5% dextrose injection, usp 50 0409-7923-13 5% dextrose injection, usp 50 0990-7923-13 5% dextrose injection, usp 50 0409-7923-23 5% dextrose injection, usp 100 0990-7923-23 5% dextrose injection, usp 100 0409-7923-37 5% dextrose injection, usp 100 0990-7923-37 5% dextrose injection, usp 100 0409-7930-02 10% dextrose injection, usp 250 0990-7930-02 10% dextrose injection, usp 250 0409-7930-03 10% dextrose injection, usp 500 0990-7930-03 , 10% dextrose injection, usp 500 0409-7930-09 10% dextrose injection, usp 1000 0990-7930-09 , 10% dextrose injection, usp 1000 store at 20 to 25°c (68 to 77°f). [see usp controlled room temperature.] protect from freezing. revised: december, 2020 ifu0000281 icumedical
Package Label Principal Display Panel:
Principal display panel - 100 ml bag label 100 ml ndc 0990-7923-37 5% dextrose injection, usp each 100 ml contains dextrose, hydrous 5 g. 252 mosmol/liter (calc). ph 4.3 (3.2 to 6.5). dextrose solutions without salts should not be used in blood transfusions because of possible rouleau formation. additives may be incompatible. single-dose container. for i.v. use. usual dosage: see insert. sterile, nonpyrogenic. use only if solution is clear and container is undamaged. must not be used in series connections. rx only icu medical, inc., lake forest, illinois, 60045, usa im-4313 3 v contains dehp icumedical principal display panel - 100 ml bag label
Principal display panel - 250 ml bag label 250 ml ndc 0990-7922-53 5% dextrose injection, usp each 100 ml contains dextrose, hydrous 5 g in water for injection. 252 mosmol/liter (calc.) ph 4.3 (3.2 to 6.5) dextrose solutions without salts should not be used in blood transfusions because of possible rouleau formation. additives may be incompatible. consult with pharmacist, if available. when introducing additives, use aseptic technique, mix thoroughly and do not store. single-dose container. for i.v. use. usual dosage: see insert. sterile, nonpyrogenic. use only if solution is clear and container is undamaged. must not be used in series connections. rx only 3 v contains dehp im-4428 manufactured for icu medical, inc., lake forest, illinois, 60045, usa icumedical principal display panel - 250 ml bag label
Principal display panel - 500 ml bag label 500 ml ndc 0990-7930-03 10% dextrose injection, usp each 100 ml contains dextrose, hydrous 10 g in water for injection. 505 mosmol/liter (calc.) ph 4.3 (3.2 to 6.5) dextrose solutions without salts should not be used in blood transfusions because of possible rouleau formation. additives may be incompatible. consult with pharmacist, if available. when introducing additives, use aseptic technique, mix thoroughly and do not store. single-dose container. for intravenous or subcutaneous use. usual dosage: see insert. sterile, nonpyrogenic. use only if solution is clear and container is undamaged. must not be used in series connections. rx only 3 v contains dehp icumedical icu medical, inc., lake forest, illinois, 60045, usa im-4454 principal display panel - 500 ml bag label