Product Elements:
Sodium bicarbonate sodium bicarbonate sodium bicarbonate sodium cation bicarbonate ion water sodium bicarbonate sodium bicarbonate sodium bicarbonate sodium cation bicarbonate ion water
Indications and Usage:
Indications and usage sodium bicarbonate injection, usp is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products. sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. treatment of metabolic acidosis should, if possible, be superimposed on measures designed to control the basic cause of the acidosis â e.g., insulin in uncomplicated diabetes, blood volume rest
Read more...oration in shock. but since an appreciable time interval may elapse before all of the ancillary effects are brought about, bicarbonate therapy is indicated to minimize risks inherent to the acidosis itself. vigorous bicarbonate therapy is required in any form of metabolic acidosis where a rapid increase in plasma total co 2 content is crucial â e.g., cardiac arrest, circulatory insufficiency due to shock or severe dehydration, and in severe primary lactic acidosis or severe diabetic acidosis.
Warnings:
Warnings solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention. in patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention. the intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema. extravascular infiltration should be avoided, see adverse reactions .
Dosage and Administration:
Dosage and administration sodium bicarbonate injection, usp is administered by the intravenous route. in cardiac arrest, a rapid intravenous dose of one to two 50 ml syringes (44.6 to 100 meq) may be given initially and continued at a rate of 50 ml (44.6 to 50 meq) every 5 to 10 minutes if necessary (as indicated by arterial ph and blood gas monitoring) to reverse the acidosis. caution should be observed in emergencies where very rapid infusion of large quantities of bicarbonate is indicated. bicarbonate solutions are hypertonic and may produce an undesirable rise in plasma sodium concentration in the process of correcting the metabolic acidosis. in cardiac arrest, however, the risks from acidosis exceed those of hypernatremia. in less urgent forms of metabolic acidosis, sodium bicarbonate injection, usp may be added to other intravenous fluids. the amount of bicarbonate to be given to older children and adults over a four-to-eight-hour period is approximately 2 to 5 meq/kg of body wei
Read more...ght â depending upon the severity of the acidosis as judged by the lowering of total co 2 content, blood ph and clinical condition of the patient. in metabolic acidosis associated with shock, therapy should be monitored by measuring blood gases, plasma osmolarity, arterial blood lactate, hemodynamics and cardiac rhythm. bicarbonate therapy should always be planned in a stepwise fashion since the degree of response from a given dose is not precisely predictable. initially an infusion of 2 to 5 meq/kg body weight over a period of 4 to 8 hours will produce a measurable improvement in the abnormal acid-base status of the blood. the next step of therapy is dependent upon the clinical response of the patient. if severe symptoms have abated, then the frequency of administration and the size of the dose may be reduced. in general, it is unwise to attempt full correction of a low total co 2 content during the first 24 hours of therapy, since this may be accompanied by an unrecognized alkalosis because of a delay in the readjustment of ventilation to normal. owing to this lag, the achievement of total co 2 content of about 20 meq/liter at the end of the first day of therapy will usually be associated with a normal blood ph. further modification of the acidosis to completely normal values usually occurs in the presence of normal kidney function when and if the cause of the acidosis can be controlled. values for total co 2 which are brought to normal or above normal within the first day of therapy are very likely to be associated with grossly alkaline values for blood ph, with ensuing undesired side effects. parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (see precautions .)
Contraindications:
Contraindications sodium bicarbonate injection, usp is contraindicated in patients who are losing chloride by vomiting or from continuous gastrointestinal suction, and in patients receiving diuretics known to produce a hypochloremic alkalosis.
Adverse Reactions:
Adverse reactions overly aggressive therapy with sodium bicarbonate injection, usp can result in metabolic alkalosis (associated with muscular twitchings, irritability, and tetany) and hypernatremia. inadvertent extravasation of intravenously administered hypertonic solutions of sodium bicarbonate have been reported to cause chemical cellulitis because of their alkalinity, with tissue necrosis, ulceration or sloughing at the site of infiltration. prompt elevation of the part, warmth and local injection of lidocaine or hyaluronidase are recommended to reduce the likelihood of tissue sloughing from extravasated i.v. solutions.
Overdosage:
Overdosage should alkalosis result, the bicarbonate should be stopped and the patient managed according to the degree of alkalosis present. 0.9% sodium chloride injection intravenous may be given; potassium chloride also may be indicated if there is hypokalemia. severe alkalosis may be accompanied by hyperirritability or tetany and these symptoms may be controlled by calcium gluconate. an acidifying agent such as ammonium chloride may also be indicated in severe alkalosis. (see warnings and precautions .)
Description:
Description sodium bicarbonate injection, usp is a sterile, nonpyrogenic, hypertonic solution of sodium bicarbonate (nahco 3 ) in water for injection for administration by the intravenous route as an electrolyte replenisher and systemic alkalizer. solutions are offered in concentrations of 7.5% and 8.4%. see table in how supplied section for contents and characteristics. the solutions have an approximate ph of 8.0 (7.0 to 8.5). they contain no bacteriostat, antimicrobial agent or added buffer and are intended only for use as a single-dose injection. when smaller doses are required, the unused portion should be discarded with the entire unit. sodium bicarbonate, 84 mg is equal to one milliequivalent each of na + and hco 3 ¯. sodium bicarbonate, usp is chemically designated nahco 3 , a white crystalline powder soluble in water. water for injection, usp is chemically designated h 2 o.
Clinical Pharmacology:
Clinical pharmacology intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood ph and reverses the clinical manifestations of acidosis. sodium bicarbonate in water dissociates to provide sodium (na + ) and bicarbonate (hco 3 ¯) ions. sodium (na + ) is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. bicarbonate (hco 3 ¯) is a normal constituent of body fluids and the normal plasma level ranges from 24 to 31 meq/liter. plasma concentration is regulated by the kidney through acidification of the urine when there is a deficit or by alkalinization of the urine when there is an excess. bicarbonate anion is considered "labile" since at a proper concentration of hydrogen ion (h + ) it may be converted to carbonic acid (h 2 co 3 ) and thence to its volatile form, carbon dioxide (co 2 ) excreted by the lung. normally a ratio of 1:20 (carbonic acid
Read more...; bicarbonate) is present in the extracellular fluid. in a healthy adult with normal kidney function, practically all the glomerular filtered bicarbonate ion is reabsorbed; less than 1% is excreted in the urine.
How Supplied:
How supplied sodium bicarbonate injection, usp is supplied in the following dosage forms. ndc no. (unit of sale) (ndc no. (each)) dosage form conc. % mg/ml (nahco 3 ) meq/ml (na + ) meq/ml (hco 3 â ) meq/ container size (ml) mosm / ml ph 0409-4916-14 (0409-4916-24) lifeshield ® abboject ® syringe 7.5 75 0.9 0.9 44.6/50 1.40 8.0 (7.0 â 8.5) 0409-6637-14 (0409-6637-24) lifeshield ® abboject ® syringe 8.4 84 1 1 50/50 1.56 8.0 (7.0 â 8.5) store at 20 to 25°c (68 to 77°f). [see usp controlled room temperature.] protect from freezing. hospira, inc., lake forest, il 60045 usa abboject ® is a trademark of the abbott group of companies. lifeshield ® is the trademark of icu medical, inc. and is used under license. lab-1019-3.0 01/2018 hospira logo
Package Label Principal Display Panel:
Principal display panel - 0.9 meq/ml syringe label 7.5% sodium bicarbonate 50 ml single-dose ndc 0409-4916-24 7.5% sodium bicarbonate injection, usp 44.6 meq/50 ml (0.9 meq/ml) rx only for intravenous use. usual dosage: see insert. sterile, nonpyrogenic. discard unused portion. 1.40 mosmol/ml. ph 8.0 (7.0 to 8.5) rl - 6883 hospira, inc., lake forest, il 60045 usa hospira principal display panel - 0.9 meq/ml syringe label
Principal display panel - 0.9 meq/ml syringe carton 50 ml ndc 0409-4916-24 7.5% sodium bicarbonate injection, usp 44.6 meq/50 ml (0.9 meq/ml) lifeshield ® glass abboject ® unit of use syringe for intravenous use with male luer lock adapter and 18-gauge protected needle rx only hospira â press and pull to open principal display panel - 0.9 meq/ml syringe carton
Principal display panel - 1 meq/ml syringe label 8.4% sodium bicarbonate 50 ml single-dose ndc 0409-6637-24 8.4% sodium bicarbonate injection, usp 50 meq/50 ml (1 meq/ml) rx only for intravenous use. usual dosage: see insert. sterile, nonpyrogenic. discard unused portion. 1.56 mosmol/ml. ph 8.0 (7.0 to 8.5). rl - 6882 hospira, inc., lake forest, il 60045 usa hospira principal display panel - 1 meq/ml syringe label
Principal display panel - 1 meq/ml syringe carton 50 ml ndc 0409-6637-24 8.4% sodium bicarbonate injection, usp 50 meq/50 ml (1 meq/ml) lifeshield ® glass abboject ® unit of use syringe for intravenous use with male luer lock adapter and 18-gauge protected needle rx only hospira â push and pull to open principal display panel - 1 meq/ml syringe carton