Potassium Chloride is a human prescription drug labeled by 'Henry Schein, Inc.'. National Drug Code (NDC) number for Potassium Chloride is 0404-9936. This drug is available in dosage form of Injection, Solution, Concentrate. The names of the active, medicinal ingredients in Potassium Chloride drug includes Potassium Chloride - 2 meq/mL . The currest status of Potassium Chloride drug is Active.

Potassium chloride potassium chloride potassium chloride potassium cation potassium hydroxide

Indications and usage potassium chloride for injection concentrate, usp is indicated in the treatment of potassium deficiency states when oral replacement is not feasible.

Warnings warning: this product contains aluminum that may be toxic. aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. tissue loading may occur at even lower rates of administration. to avoid potassium intoxication, do not infuse these solutions rapidly. in patients with renal insufficiency , administration of potassium chloride may cause potassium intoxication and life-threatening hyperkalemia. the administration of intravenous solutions can cause fluid and/or solute overload resulting in dilution of serum elec Read more...

Dosage and administration potassium chloride for injection concentrate must be diluted before administration. care must be taken to ensure there is complete mixing of the potassium chloride with the large volume fluid, particularly if soft of bag type containers are used. the dose and rate of administration are dependent upon the specific condition of each patient. if the serum potassium level is greater than 2.5 meq/l, potassium can be given at a rate not to exceed 10 meq/hour and in a concentration of up to 40 meq/l. the 24 hour total dose should not exceed 200 meq. if urgent treatment is indicated (serum potassium level less than 2meq/l and electrocardiographic changes and/or muscle paralysis), potassium chloride may be infused very cautiously at a rate of up to 40 meq/hour. in such cases, continuous cardiac monitoring is essential. as much as 400 meq may be administered in a 24 hour period. in critical conditions, potassium chloride may be administered in saline (unless contraindic Read more...

Contraindications potassium chloride for injection concentrate is contraindicated in diseases where high potassium levels may be encountered, and in patients with hyperkalemia, renal failure and in conditions in which potassium retention is present.

Adverse reactions reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phelbitis extending from the site of injection, extravasation, hypervolemia, and hyperkalemia. too rapid infusion of hypertonic solutions may cause local pain and, rarely, vein irritation. rate of administration should be adjusted according to tolerance. reactions reported with the use of potassium-containing solutions include nausea, vomiting, abdominal pain and diarrhea. the signs and symptoms of potassium intoxication include paresthesias of the extremities, areflexia, muscular or respiratory paralysis, mental confusion, weakness, hypotension, cardiac arrhythmias, heart block, electrocardiographic abnormalities and cardiac arrest. potassium deficits result in disruption or neuromuscular function, and intestinal ileus and dilatation. if an adverse reaction does occur, discontinue the infusion, evaluat Read more...

Overdosage in the event of fluid overload during parenteral therapy, reevaluate the patient's condition, and institute appropriate corrective treatment. in the even of overdosage with potassium-containing solutions, discontinue the infusion immediately and institute corrective therapy to reduce serum potassium levels. treatment of hyperkalemia includes the following: dextrose injection, usp 10% or 25%, containing 10 units of crystalline insulin per 20 grams of dextrose administered intravenously, 300 to 500 ml/hour. absorption and exchange of potassium using sodium or ammonium cycle cation exchange resin, orally and as retention enema. hemodialysis and peritoneal dialysis. the use of potassium-containing foods or medications must be eliminated. however, in cases of digitalization, too rapid a lowering of plasma potassium concentration can cause digitalis toxicity.

Description concentrate must be diluted before use for intravenous infusion only must be diluted prior to injection potassium chloride for injection concentrate, usp is a sterile, nonpyrogenic concentrated solution of potassium chloride, sup in water for injection to be administered by intravenous infusion only after dilution in a larger volume of fluid. each ml of potassium chloride for injection concentrate contains 2 meq of k+ and cl-equivalent to 149 mg of potassium chloride and has an osmalarity of 4000 mosmol/l (calc). a more concentrated potassium chloride for injection concentrate is also available. each ml of this injection contains 3 meq of k+ and cl- equivalent to 224 mg of potassium chloride and has an osmolarity of 6000 mosmol/l (calc). ph (4.0-8.0) may have been adjusted with hydrochloric acid and if necessary, potassium hydroxide. some packages are intended for multiple dose use and contain preservatives (0,05% methylparaben and 0.005% propylparaben). a summary of the available products is presented in the how supplied section. potassium chloride for injection concentrate (appropriately diluted) is a parenteral fluid and electrolyte replenisher.

Clinical pharmacology potassium is the chief cation of body cells (160 meq/l) of intracellular water) and is concenrtned with the maintenance of body fluid composition and electrolyte balance. potassium participates in carbohydrate utilization and protein synthesis, and is critical in the regulation of nerve conduction and muscle contraction, particularly in the heart. chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration. normally about 80-90% of the potassium intake is excreted in the urine, the remainder in the stools and to a small extent, in the perspiration. the kidney does not conserve potassium well, so that during fasting, or in patients on a potassium-free diet, potassium loss from the body continues resulting in potassium depletion. a deficiency of either potassium or chloride will lead to a deficit of the other.

How supplied the following are packaged in plastic vials. these are single dose vials, no preservative added, packaged 25 vials per tray. unused portion of vial should be discarded. this is a multiple dose vial, preserved with 0.05% methylparaben and 0.005% propylparaben, packaged 25 vials per tray. store at 20° to 25°c (68° to 77°f) [see usp controlled room temperature]. use only if solution is clear, seal intact and undamaged. vial stoppers do not contain natural rubber latex. product repackaged by: henry schein, inc., bastian, va 24314 from original manufacturer/distributor's ndc and unit of sale to henry schein repackaged product ndc and unit of sale total strength/total volume (concentration) per unit ndc 63323-965-05 unit of 25 ndc 0404-9936-10 1 5 ml in a 10 ml single dose vial in a bag (vial bears ndc 63323-965-01) 10 meq (0.39 g) 149 mg per ml ndc 63323-965-20 unit of 25 ndc 0404-9936-20 1 20 ml single dose vial in a bag (vial bears ndc 63323-965-02) 40 meq (1.56 g Read more...

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